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10.1038/s41598-018-26470-w http://scihub22266oqcxt.onion/10.1038/s41598-018-26470-w C5974230!5974230!29844470     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29844470|t=2018. Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice |pdf=|usr=}}{{29844470}} gab.com Text Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29844470 #FOAvip Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (?-GalCer) or vehicle once a week for four weeks. In the ?-GalCer group, the levels of proteinuria and blood urea nitrogen were significantly lower than those in the vehicle group. The histological evaluation showed a decrease in glomerular immune complex deposits and an alleviation of podocyte injury. The proportion of NKT cells in the mononuclear cell (MNC) fraction in the ?-GalCer group was significantly decreased in the liver, kidney, and spleen. The proliferation and cytokine production in ?-GalCer-stimulated liver MNCs were markedly diminished in the ?-GalCer group (anergy). The IFN-? production in liver MNCs stimulated by concanavalin A or an anti-CD3 antibody did not differ between the two groups, whereas the IL-4 production was significantly lower in the ?-GalCer group. In addition, the IgM production in CpG-oligodeoxynucleotide-stimulated spleen MNCs was significantly lower in the ?-GalCer group. These results suggest that ?-GalCer suppressed Th2 immune responses in NKT cells and B cell function, thereby slowing the progression of lupus nephritis. Twit Text FOAVip Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29844470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844470 #FOAvip English Wikipedia <ref>{{Cite pmid|29844470}}</ref> Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice #MMPMID29844470 Uchida T; Nakashima H; Yamagata A; Ito S; Ishikiriyama T; Nakashima M; Seki S; Kumagai H; Oshima N Sci Rep 2018[]; 8 (ä): ä PMID29844470show ga Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (?-GalCer) or vehicle once a week for four weeks. In the ?-GalCer group, the levels of proteinuria and blood urea nitrogen were significantly lower than those in the vehicle group. The histological evaluation showed a decrease in glomerular immune complex deposits and an alleviation of podocyte injury. The proportion of NKT cells in the mononuclear cell (MNC) fraction in the ?-GalCer group was significantly decreased in the liver, kidney, and spleen. The proliferation and cytokine production in ?-GalCer-stimulated liver MNCs were markedly diminished in the ?-GalCer group (anergy). The IFN-? production in liver MNCs stimulated by concanavalin A or an anti-CD3 antibody did not differ between the two groups, whereas the IL-4 production was significantly lower in the ?-GalCer group. In addition, the IgM production in CpG-oligodeoxynucleotide-stimulated spleen MNCs was significantly lower in the ?-GalCer group. These results suggest that ?-GalCer suppressed Th2 immune responses in NKT cells and B cell function, thereby slowing the progression of lupus nephritis. äRepeated administration of alpha-galactosylceramide ameliorates experi(epmc).pdf DeepDyve Pubget Overpricing