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10.1038/s41598-018-26115-y

http://scihub22266oqcxt.onion/10.1038/s41598-018-26115-y
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C5973942!5973942!29844319
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suck abstract from ncbi


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pmid29844319      Sci+Rep 2018 ; 8 (ä): ä
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  • Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure #MMPMID29844319
  • Nguyen MN; Su Y; Vizi D; Fang L; Ellims AH; Zhao WB; Kiriazis H; Gao XM; Sadoshima J; Taylor AJ; McMullen JR; Dart AM; Kaye DM; Du XJ
  • Sci Rep 2018[]; 8 (ä): ä PMID29844319show ga
  • Galectin-3 is a biomarker of heart disease. However, it remains unknown whether increase in galectin-3 levels is dependent on aetiology or disease-associated conditions and whether diseased heart releases galectin-3 into the circulation. We explored these questions in mouse models of heart disease and in patients with cardiomyopathy. All mouse models (dilated cardiomyopathy, DCM; fibrotic cardiomyopathy, ischemia-reperfusion, I/R; treatment with ?-adrenergic agonist isoproterenol) showed multi-fold increases in cardiac galectin-3 expression and preserved renal function. In mice with fibrotic cardiomyopathy, I/R or isoproterenol treatment, plasma galectin-3 levels and density of cardiac inflammatory cells were elevated. These models also exhibited parallel changes in cardiac and plasma galectin-3 levels and presence of trans-cardiac galectin-3 gradient, indicating cardiac release of galectin-3. DCM mice showed no change in circulating galectin-3 levels nor trans-cardiac galectin-3 gradient or myocardial inflammatory infiltration despite a 50-fold increase in cardiac galectin-3 content. In patients with hypertrophic cardiomyopathy or DCM, plasma galectin-3 increased only in those with renal dysfunction and a trans-cardiac galectin-3 gradient was not present. Collectively, this study documents the aetiology-dependency and diverse mechanisms of increment in circulating galectin-3 levels. Our findings highlight cardiac inflammation and enhanced ?-adrenoceptor activation in mediating elevated galectin-3 levels via cardiac release in the mechanism.
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