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http://scihub22266oqcxt.onion/ C5973875!5973875!29854880     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JSM+Biochem+Mol+Biol 2016 ; 3 (1): ä Nephropedia Template TP {{tp|p=29854880|t=2016. The Journey of Protein S from an Anticoagulant to a Signaling Molecule |pdf=|usr=}}{{29854880}} gab.com Text The Journey of Protein S from an Anticoagulant to a Signaling Molecule JO: JSM Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=29854880 #FOAvip Protein S (PS), a ?-carboxyglutamate-containing serum protein, was unexpectedly discovered in 1977. Soon after its discovery, PS gained the attention of researchers because of its physiological importance, acting as a multifunctional protein at the intersection of blood coagulation, inflammation, and other cellular processes. Protein S functions as an anticoagulant by directly inhibiting procoagulants, such as Factor Xa (FXa), FVa, and FIXa, while also serving as a cofactor for anticoagulants such as Activated Protein C and Tissue Factor Pathway Inhibitor. By associating with C4b binding protein (C4BP), PS has also been shown to minimize the effect of inflammation. Finally, PS promotes efferocytosis through TAM family protein kinase receptors. Mutations in the PS gene cause pathological conditions such as deep vein thrombosis and hereditary ischemia. In this review, we summarize studies regarding the multiple functions of PS. Twit Text FOAVip The Journey of Protein S from an Anticoagulant to a Signaling Molecule ????JSM Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=29854880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29854880 #FOAvip English Wikipedia <ref>{{Cite pmid|29854880}}</ref> The Journey of Protein S from an Anticoagulant to a Signaling Molecule #MMPMID29854880 Pilli V; Plautz W; Majumder R JSM Biochem Mol Biol 2016[]; 3 (1): ä PMID29854880show ga Protein S (PS), a ?-carboxyglutamate-containing serum protein, was unexpectedly discovered in 1977. Soon after its discovery, PS gained the attention of researchers because of its physiological importance, acting as a multifunctional protein at the intersection of blood coagulation, inflammation, and other cellular processes. Protein S functions as an anticoagulant by directly inhibiting procoagulants, such as Factor Xa (FXa), FVa, and FIXa, while also serving as a cofactor for anticoagulants such as Activated Protein C and Tissue Factor Pathway Inhibitor. By associating with C4b binding protein (C4BP), PS has also been shown to minimize the effect of inflammation. Finally, PS promotes efferocytosis through TAM family protein kinase receptors. Mutations in the PS gene cause pathological conditions such as deep vein thrombosis and hereditary ischemia. In this review, we summarize studies regarding the multiple functions of PS. äThe Journey of Protein S from an Anticoagulant to a Signaling Molecule(epmc).pdf DeepDyve Pubget Overpricing