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10.1080/19491034.2017.1421825 http://scihub22266oqcxt.onion/10.1080/19491034.2017.1421825 C5973195!5973195!29300120     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleus 2018 ; 9 (1): 95-103 Nephropedia Template TP {{tp|p=29300120|t=2018. Extrusion without a motor: a new take on the loop extrusion model of genome organization |pdf=|usr=}}{{29300120}} gab.com Text Extrusion without a motor: a new take on the loop extrusion model of genome organization JO: Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=29300120 #FOAvip Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is the only model to date which can explain this. However, the model requires a motor to generate the loops, and although cohesin is a strong candidate for the extruding factor, a suitable motor protein (or a motor activity in cohesin itself) has yet to be found. Here we explore a new hypothesis: that there is no motor, and thermal motion within the nucleus drives extrusion. Using theoretical modelling and computer simulations we ask whether such diffusive extrusion could feasibly generate loops. Our simulations uncover an interesting ratchet effect (where an osmotic pressure promotes loop growth), and suggest, by comparison to recent in vitro and in vivo measurements, that diffusive extrusion can in principle generate loops of the size observed in the data. Extra View on : C. A. Brackley, J. Johnson, D. Michieletto, A. N. Morozov, M. Nicodemi, P. R. Cook, and D. Marenduzzo ?Non-equilibrium chromosome looping via molecular slip-links?, Physical Review Letters 119 138101 (2017) Twit Text FOAVip Extrusion without a motor: a new take on the loop extrusion model of genome organization ????Nucleus http://www.kidney.de/pget.php?&tw=1&pmid=29300120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29300120 #FOAvip English Wikipedia <ref>{{Cite pmid|29300120}}</ref> Extrusion without a motor: a new take on the loop extrusion model of genome organization #MMPMID29300120 Brackley CA; Johnson J; Michieletto D; Morozov AN; Nicodemi M; Cook PR; Marenduzzo D Nucleus 2018[]; 9 (1): 95-103 PMID29300120show ga Chromatin loop extrusion is a popular model for the formation of CTCF loops and topological domains. Recent HiC data have revealed a strong bias in favour of a particular arrangement of the CTCF binding motifs that stabilize loops, and extrusion is the only model to date which can explain this. However, the model requires a motor to generate the loops, and although cohesin is a strong candidate for the extruding factor, a suitable motor protein (or a motor activity in cohesin itself) has yet to be found. Here we explore a new hypothesis: that there is no motor, and thermal motion within the nucleus drives extrusion. Using theoretical modelling and computer simulations we ask whether such diffusive extrusion could feasibly generate loops. Our simulations uncover an interesting ratchet effect (where an osmotic pressure promotes loop growth), and suggest, by comparison to recent in vitro and in vivo measurements, that diffusive extrusion can in principle generate loops of the size observed in the data. Extra View on : C. A. Brackley, J. Johnson, D. Michieletto, A. N. Morozov, M. Nicodemi, P. R. Cook, and D. Marenduzzo ?Non-equilibrium chromosome looping via molecular slip-links?, Physical Review Letters 119 138101 (2017) äExtrusion without a motor: a new take on the loop extrusion model of g(epmc).pdf DeepDyve Pubget Overpricing