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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neuropsychiatry+Clin+Neurosci
1997 ; 9
(1
): 75-80
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Elevated plasma gamma-aminobutyric acid (GABA) levels in individuals with either
Prader-Willi syndrome or Angelman syndrome
#MMPMID9017532
Ebert MH
; Schmidt DE
; Thompson T
; Butler MG
J Neuropsychiatry Clin Neurosci
1997[Win]; 9
(1
): 75-80
PMID9017532
show ga
Plasma gamma-aminobutyric acid (GABA) levels were measured in 14 subjects with
Prader-Willi syndrome, 9 subjects with Angelman syndrome, and matched control
subjects. Mean levels in both patient groups were 2 to 3 times higher than in
nonretarded moderately obese or retarded nonobese control subjects. Levels in
each patient group differed significantly from both control groups. Neither the
two patient groups nor the two control groups differed. GABA levels seemed
unrelated to genetic status (chromosome 15 deletion or disomy). These preliminary
findings of elevated plasma GABA levels possibly represent a compensatory
increase in presynaptic GABA release in response to hyposensitivity of a subset
of GABA receptors and could produce increased postsynaptic activation of other
normal GABA receptor subtypes, resulting in complex alterations of GABAergic
function throughout the brain.