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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Gen+Virol
2016 ; 97
(1
): 1-17
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English Wikipedia
Role of the single deaminase domain APOBEC3A in virus restriction,
retrotransposition, DNA damage and cancer
#MMPMID26489798
Wang Y
; Schmitt K
; Guo K
; Santiago ML
; Stephens EB
J Gen Virol
2016[Jan]; 97
(1
): 1-17
PMID26489798
show ga
The apolipoprotein mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3; A3)
proteins are a family of seven cytidine deaminases (A3A, A3B, A3C, A3D, A3F, A3G
and A3H) that restrict certain viral infections. These innate defence factors are
best known for their ability to restrict the replication of human
immunodeficiency virus type 1 (HIV-1) lacking a functional Vif protein
(HIV-1?vif) through the deamination of cytidine residues to uridines during
reverse transcription, ultimately leading to lethal G???A changes in the viral
genome. The best studied of the A3 proteins has been APOBEC3G because of its
potent activity against HIV-1?vif. However, one member of this family, A3A, has
biological properties that make it unique among the A3 proteins. In this review,
we will focus on the structural and phylogenetic features of the human and
non-human primate A3A proteins, their role in the restriction of retroviruses and
other viruses, and current findings on other biological properties affected by
this protein.