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Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Int+Med+Res 2018 ; 46 (3): 1162-71 Nephropedia Template TP
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Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study #MMPMID29235391
Kokic V; Martinovic Kaliterna D; Radic M; Tandara L; Perkovic D
J Int Med Res 2018[Mar]; 46 (3): 1162-71 PMID29235391show ga
Objectives: To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFN?) in female patients with inactive systemic lupus erythematosus (SLE). Methods: Female patients with inactive SLE and age-matched healthy controls were recruited into this cross-sectional study. Serum concentrations of 25(OH)D3, E2 and IFN? were measured by radioimmunoassay with gamma-counters and enzyme-linked immunosorbent assay. Results: 36 patients and 37 controls were enrolled. In patients with SLE, the concentration of 25(OH)D3 was lower and E2 was higher compared with controls. In vitamin D deficient (i.e., 25(OH)D3?20?ng/ml) patients, IFN? was 150% higher compared with patients with 25(OH)D3>20?ng/ml and controls. The concentration of E2 was higher in all patients compared with controls independently of the vitamin D level. A difference was found between patients and controls in the correlation of 25(OH)D3 with E2 and a positive correlation was found between E2 and IFN? in all participants. Conclusions: Our results suggest that E2 may have a strong modulating effect on vitamin D function which is significant only at low concentration of E2.