Association between vitamin D, oestradiol and interferon-gamma in female patients
with inactive systemic lupus erythematosus: A cross-sectional study
#MMPMID29235391
Kokic V
; Martinovic Kaliterna D
; Radic M
; Tandara L
; Perkovic D
J Int Med Res
2018[Mar]; 46
(3
): 1162-1171
PMID29235391
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Objectives To investigate possible associations between 25-hydroxyvitamin D(3)
(25(OH)D(3)), oestradiol (E(2)) and IFN-gamma (IFN?) in female patients with
inactive systemic lupus erythematosus (SLE). Methods Female patients with
inactive SLE and age-matched healthy controls were recruited into this
cross-sectional study. Serum concentrations of 25(OH)D(3,) E(2) and IFN? were
measured by radioimmunoassay with gamma-counters and enzyme-linked immunosorbent
assay. Results 36 patients and 37 controls were enrolled. In patients with SLE,
the concentration of 25(OH)D(3) was lower and E(2) was higher compared with
controls. In vitamin D deficient (i.e., 25(OH)D(3)?20?ng/ml) patients, IFN? was
150% higher compared with patients with 25(OH)D(3)>20?ng/ml and controls. The
concentration of E(2) was higher in all patients compared with controls
independently of the vitamin D level. A difference was found between patients and
controls in the correlation of 25(OH)D(3) with E(2) and a positive correlation
was found between E(2) and IFN? in all participants. Conclusions Our results
suggest that E(2) may have a strong modulating effect on vitamin D function which
is significant only at low concentration of E(2).
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