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10.1186/s12931-018-0786-z http://scihub22266oqcxt.onion/10.1186/s12931-018-0786-z C5970521!5970521 !29801490     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29801490 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation |pdf=|usr=}}{{29801490 }} gab.com Text Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=29801490 #FOAvip BACKGROUND: Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as potential biomarkers of lung allograft rejection or dysfunction. However, BAL collection is not well standardized and differences in BAL collection represent an important source of variation. We hypothesized that there are systematic differences between sequential BALs that are relevant to BAL analysis. METHODS: As part of 126 consecutive bronchoscopies in lung transplant recipients, two sequential BALs (BAL1 and BAL2) were performed in one location during each bronchoscopy by instilling and suctioning 50 ml of normal saline twice into separate containers. Cell concentration, viability and differentials, Surfactant Protein-D (SP-D), Club Cell Secretory Protein (CCSP), and levels of CXCL10, IL-10, CCL2, CCL5, VEGF-C, RAGE, CXCL9, CXCL1, IL-17A, IL-21, PDGF, and GCSF were compared between BAL1 and BAL2. RESULTS: Total cell concentration did not differ between BAL1 and BAL2; however, compared to BAL2, BAL1 had more dead cells, epithelial cells, neutrophils, and higher concentrations of airway epithelium-derived CCSP and inflammatory markers. BAL2 had a higher concentration of SP-D compared to BAL1. CONCLUSION: In this study performed in lung transplant recipients, we show that sequential BALs represent different lung compartments and have distinct compositions. BAL1 represents the airway compartment with more epithelial cells, neutrophils, and epithelium-derived CCSP. Conversely, BAL2 samples preferentially the distal bronchoalveolar space with greater cell viability and higher SP-D. Our findings illustrate how the method of BAL collection can influence analyte concentrations and further emphasize the need for a standardized approach in translational research involving BAL samples. Twit Text FOAVip Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=29801490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29801490 #FOAvip English Wikipedia <ref>{{Cite pmid|29801490 }}</ref> Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation #MMPMID29801490 Levy L ; Juvet SC ; Boonstra K ; Singer LG ; Azad S ; Joe B ; Cypel M ; Keshavjee S ; Martinu T Respir Res 2018[May]; 19 (1 ): 102 PMID29801490 show ga BACKGROUND: Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as potential biomarkers of lung allograft rejection or dysfunction. However, BAL collection is not well standardized and differences in BAL collection represent an important source of variation. We hypothesized that there are systematic differences between sequential BALs that are relevant to BAL analysis. METHODS: As part of 126 consecutive bronchoscopies in lung transplant recipients, two sequential BALs (BAL1 and BAL2) were performed in one location during each bronchoscopy by instilling and suctioning 50 ml of normal saline twice into separate containers. Cell concentration, viability and differentials, Surfactant Protein-D (SP-D), Club Cell Secretory Protein (CCSP), and levels of CXCL10, IL-10, CCL2, CCL5, VEGF-C, RAGE, CXCL9, CXCL1, IL-17A, IL-21, PDGF, and GCSF were compared between BAL1 and BAL2. RESULTS: Total cell concentration did not differ between BAL1 and BAL2; however, compared to BAL2, BAL1 had more dead cells, epithelial cells, neutrophils, and higher concentrations of airway epithelium-derived CCSP and inflammatory markers. BAL2 had a higher concentration of SP-D compared to BAL1. CONCLUSION: In this study performed in lung transplant recipients, we show that sequential BALs represent different lung compartments and have distinct compositions. BAL1 represents the airway compartment with more epithelial cells, neutrophils, and epithelium-derived CCSP. Conversely, BAL2 samples preferentially the distal bronchoalveolar space with greater cell viability and higher SP-D. Our findings illustrate how the method of BAL collection can influence analyte concentrations and further emphasize the need for a standardized approach in translational research involving BAL samples. |Adult [MESH] |Aged [MESH] |Biomedical Research/*trends [MESH] |Bronchoalveolar Lavage Fluid/*cytology [MESH] |Bronchoalveolar Lavage/*trends [MESH] |Bronchoscopy/trends [MESH] |Cohort Studies [MESH] |Female [MESH] |Humans [MESH] |Lung Transplantation/*trends [MESH] |Lung/*pathology/surgery [MESH] |Male [MESH] |Middle Aged [MESH] |Retrospective Studies [MESH]Sequential broncho-alveolar lavages reflect distinct pulmonary compart(epmc).pdf DeepDyve Pubget Overpricing