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10.1186/s12995-018-0197-6 http://scihub22266oqcxt.onion/10.1186/s12995-018-0197-6 C5970510!5970510!29849741     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Occup+Med+Toxicol 2018 ; 13 (ä): ä Nephropedia Template TP {{tp|p=29849741|t=2018. Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents |pdf=|usr=}}{{29849741}} gab.com Text Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents JO: J Occup Med Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=29849741 #FOAvip Background: Hepatitis C Virus (HCV) infections are blood-borne, generally chronic and are associated with increased morbidity and mortality. The aim of this study is to describe the results of therapies with direct-acting antiviral agents (DAAs) in healthcare personnel. Methods: Secondary data analysis using data from the Statutory Accident Insurance of the Health and Welfare Service. The study surveyed DAA therapies administered to insured parties (healthcare personnel with an HCV infection recognised as an occupational disease) in Germany between 01/01/2014 and 30/11/2016. The end points were results of monitorings carried out twelve weeks after the end of treatment (SVR12), side effects and the results of the assessment of reduced work ability after treatment. Multivariate logistic regression models were constructed to model SVR12. Results: The study population (n =?180) comprised 74% women, 90% of the participants had an HCV genotype 1 infection. Two-thirds had fibrosis or cirrhosis and were treatment experienced. The most common combined therapy was ledipasvir and sofosbuvir (49%). A DAA therapy with ribavirin was administered in 20% of cases, with (pegylated) interferon and ribavirin used in 2% of cases. The majority of therapies were completed without any side effects. The overall SVR12 rate was 94%. Significant independent predictor of decrease odds of SVR12 was liver cirrhosis. Positive effects on the healthcare personnel?s work ability were observed after successful therapy. Conclusion: High SVR12 rates were achieved in the sample population, with positive effects on their work ability. Early HCV therapy seems reasonable due to the increased chance of successful treatment of the infection. Electronic supplementary material: The online version of this article (10.1186/s12995-018-0197-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents ????J Occup Med Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=29849741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29849741 #FOAvip English Wikipedia <ref>{{Cite pmid|29849741}}</ref> Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents #MMPMID29849741 Westermann C; Wendeler D; Nienhaus A J Occup Med Toxicol 2018[]; 13 (ä): ä PMID29849741show ga Background: Hepatitis C Virus (HCV) infections are blood-borne, generally chronic and are associated with increased morbidity and mortality. The aim of this study is to describe the results of therapies with direct-acting antiviral agents (DAAs) in healthcare personnel. Methods: Secondary data analysis using data from the Statutory Accident Insurance of the Health and Welfare Service. The study surveyed DAA therapies administered to insured parties (healthcare personnel with an HCV infection recognised as an occupational disease) in Germany between 01/01/2014 and 30/11/2016. The end points were results of monitorings carried out twelve weeks after the end of treatment (SVR12), side effects and the results of the assessment of reduced work ability after treatment. Multivariate logistic regression models were constructed to model SVR12. Results: The study population (n =?180) comprised 74% women, 90% of the participants had an HCV genotype 1 infection. Two-thirds had fibrosis or cirrhosis and were treatment experienced. The most common combined therapy was ledipasvir and sofosbuvir (49%). A DAA therapy with ribavirin was administered in 20% of cases, with (pegylated) interferon and ribavirin used in 2% of cases. The majority of therapies were completed without any side effects. The overall SVR12 rate was 94%. Significant independent predictor of decrease odds of SVR12 was liver cirrhosis. Positive effects on the healthcare personnel?s work ability were observed after successful therapy. Conclusion: High SVR12 rates were achieved in the sample population, with positive effects on their work ability. Early HCV therapy seems reasonable due to the increased chance of successful treatment of the infection. Electronic supplementary material: The online version of this article (10.1186/s12995-018-0197-6) contains supplementary material, which is available to authorized users. äHepatitis C in healthcare personnel: secondary data analysis of therap(epmc).pdf DeepDyve Pubget Overpricing