Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-018-04408-0 http://scihub22266oqcxt.onion/10.1038/s41467-018-04408-0 C5970247!5970247!29802242     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29802242|t=2018. Testosterone is an endogenous regulator of BAFF and splenic B cell number |pdf=|usr=}}{{29802242}} gab.com Text Testosterone is an endogenous regulator of BAFF and splenic B cell number JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29802242 #FOAvip Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an ?-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity. Twit Text FOAVip Testosterone is an endogenous regulator of BAFF and splenic B cell number ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29802242 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29802242 #FOAvip English Wikipedia <ref>{{Cite pmid|29802242}}</ref> Testosterone is an endogenous regulator of BAFF and splenic B cell number #MMPMID29802242 Wilhelmson AS; Lantero Rodriguez M; Stubelius A; Fogelstrand P; Johansson I; Buechler MB; Lianoglou S; Kapoor VN; Johansson ME; Fagman JB; Duhlin A; Tripathi P; Camponeschi A; Porse BT; Rolink AG; Nissbrandt H; Turley SJ; Carlsten H; Mårtensson IL; Karlsson MCI; Tivesten Å Nat Commun 2018[]; 9 (ä): ä PMID29802242show ga Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an ?-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity. äTestosterone is an endogenous regulator of BAFF and splenic B cell num(epmc).pdf DeepDyve Pubget Overpricing