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10.1038/s41598-018-26531-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-26531-0 C5970155!5970155 !29802350     free     free     free       Sci+Rep 2018 ; 8 (1 ): 8159 Nephropedia Template TP {{tp|p=29802350 |t=2018. Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis |pdf=|usr=}}{{29802350 }} gab.com Text Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29802350 #FOAvip Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX values in 128 treatment-naïve, histologically assessed primary biliary cholangitis (PBC) patients and 80 healthy controls for comparisons of clinical parameters in a case-control study. The median ATX concentrations in controls and PBC patients of Nakanuma's stage I, II, III, and IV were 0.70, 0.80, 0.87, 1.03, and 1.70?mg/L, respectively, which increased significantly with disease stage (r?=?0.53, P?<?0.0001) as confirmed by Scheuer's classification (r?=?0.43, P?<?0.0001). ATX correlated with Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) (r?=?0.51, P?<?0.0001) and fibrosis index based on four factors (FIB-4) index (r?=?0.51, P?<?0.0001). While ALP and M2BPGi levels had decreased significantly (both P?<?0.001) by 12 months of ursodeoxycholic acid treatment, ATX had not (0.95 to 0.96?mg/L) (P?=?0.07). We observed in a longitudinal study that ATX increased significantly (P?<?0.00001) over 18 years in an independent group of 29 patients. Patients succumbing to disease-related death showed a significantly higher ATX increase rate (0.05?mg/L/year) than did survivors (0.02?mg/L/year) (P?<?0.01). ATX therefore appears useful for assessing disease stage and prognosis in PBC. Twit Text FOAVip Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29802350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29802350 #FOAvip English Wikipedia <ref>{{Cite pmid|29802350 }}</ref> Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis #MMPMID29802350 Joshita S ; Umemura T ; Usami Y ; Yamashita Y ; Norman GL ; Sugiura A ; Yamazaki T ; Fujimori N ; Kimura T ; Matsumoto A ; Igarashi K ; Yoshizawa K ; Ota M ; Tanaka E Sci Rep 2018[May]; 8 (1 ): 8159 PMID29802350 show ga Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX values in 128 treatment-naïve, histologically assessed primary biliary cholangitis (PBC) patients and 80 healthy controls for comparisons of clinical parameters in a case-control study. The median ATX concentrations in controls and PBC patients of Nakanuma's stage I, II, III, and IV were 0.70, 0.80, 0.87, 1.03, and 1.70?mg/L, respectively, which increased significantly with disease stage (r?=?0.53, P? |*Disease Progression [MESH] |Adult [MESH] |Aged [MESH] |Biomarkers/blood [MESH] |Case-Control Studies [MESH] |Female [MESH] |Humans [MESH] |Liver Cirrhosis, Biliary/*blood/complications/diagnosis [MESH] |Liver Cirrhosis/complications [MESH] |Male [MESH] |Middle Aged [MESH] |Phosphoric Diester Hydrolases/*blood [MESH]Serum Autotaxin Is a Useful Disease Progression Marker in Patients wit(epmc).pdf DeepDyve Pubget Overpricing