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CD169(+) macrophages orchestrate innate immune responses by regulating bacterial
localization in the spleen
#MMPMID28986418
Perez OA
; Yeung ST
; Vera-Licona P
; Romagnoli PA
; Samji T
; Ural BB
; Maher L
; Tanaka M
; Khanna KM
Sci Immunol
2017[Oct]; 2
(16
): ? PMID28986418
show ga
The spleen is an important site for generating protective immune responses
against pathogens. After infection, immune cells undergo rapid reorganization to
initiate and maintain localized inflammatory responses; however, the mechanisms
governing this spatial and temporal cellular reorganization remain unclear. We
show that the strategic position of splenic marginal zone CD169(+) macrophages is
vital for rapid initiation of antibacterial responses. In addition to controlling
initial bacterial growth, CD169(+) macrophages orchestrate a second phase of
innate protection by mediating the transport of bacteria to splenic T cell zones.
This compartmentalization of bacteria within the spleen was essential for driving
the reorganization of innate immune cells into hierarchical clusters and for
local interferon-? production near sites of bacterial replication foci. Our
results show that both phases of the antimicrobial innate immune response were
dependent on CD169(+) macrophages, and, in their absence, the series of events
needed for pathogen clearance and subsequent survival of the host was disrupted.
Our study provides insight into how lymphoid organ structure and function are
related at a fundamental level.
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