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10.1038/nrm.2017.127 http://scihub22266oqcxt.onion/10.1038/nrm.2017.127 C5969912!5969912!29363672     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2018 ; 19 (5): 297-312 Nephropedia Template TP {{tp|p=29363672|t=2018. Once and only once: mechanisms of centriole duplication and their deregulation in disease |pdf=|usr=}}{{29363672}} gab.com Text Once and only once: mechanisms of centriole duplication and their deregulation in disease JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29363672 #FOAvip Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule related processes, including motility, cell division and cell signaling. To coordinate these diverse cellular processes, centriole number must be tightly controlled. In cycling cells, one new centriole is formed next to each preexisting centriole in every cell cycle. Advances in imaging, proteomics, structural biology and genome editing have revealed new insights into centriole biogenesis, how centriole numbers are controlled and how alterations in these structures contribute to diseases such as cancer and neurodevelopmental disorders. Moreover, recent work has uncovered the existence of surveillance pathways that limit proliferation of cells with numerical centriole aberrations. Here we discuss recent progress in this field with a focus on signaling pathways and molecular mechanisms. Twit Text FOAVip Once and only once: mechanisms of centriole duplication and their deregulation in disease ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29363672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29363672 #FOAvip English Wikipedia <ref>{{Cite pmid|29363672}}</ref> Once and only once: mechanisms of centriole duplication and their deregulation in disease #MMPMID29363672 Nigg EA; Holland AJ Nat Rev Mol Cell Biol 2018[May]; 19 (5): 297-312 PMID29363672show ga Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule related processes, including motility, cell division and cell signaling. To coordinate these diverse cellular processes, centriole number must be tightly controlled. In cycling cells, one new centriole is formed next to each preexisting centriole in every cell cycle. Advances in imaging, proteomics, structural biology and genome editing have revealed new insights into centriole biogenesis, how centriole numbers are controlled and how alterations in these structures contribute to diseases such as cancer and neurodevelopmental disorders. Moreover, recent work has uncovered the existence of surveillance pathways that limit proliferation of cells with numerical centriole aberrations. Here we discuss recent progress in this field with a focus on signaling pathways and molecular mechanisms. äOnce and only once: mechanisms of centriole duplication and their dere(epmc).pdf DeepDyve Pubget Overpricing