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Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness
advantage against sugar-induced cell death
#MMPMID29509056
de Alteriis E
; Carteń F
; Parascandola P
; Serpa J
; Mazzoleni S
Cell Cycle
2018[]; 17
(6
): 688-701
PMID29509056
show ga
The mechanisms behind the Warburg effect in mammalian cells, as well as for the
similar Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter
of debate: why do cells shift from the energy-efficient respiration to the
energy-inefficient fermentation at high sugar concentration? This review reports
on the strong similarities of these phenomena in both cell types, discusses the
current ideas, and provides a novel interpretation of their common functional
mechanism in a dynamic perspective. This is achieved by analysing another
phenomenon, the sugar-induced-cell-death (SICD) occurring in yeast at high sugar
concentration, to highlight the link between ATP depletion and cell death. The
integration between SICD and the dynamic functioning of the glycolytic process,
suggests that the Crabtree/Warburg effect may be interpreted as the avoidance of
ATP depletion in those conditions where glucose uptake is higher than the
downstream processing capability of the second phase of glycolysis. It follows
that the down-regulation of respiration is strategic for cell survival allowing
the allocation of more resources to the fermentation pathway, thus maintaining
the cell energetic homeostasis.
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