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10.1002/1873-3468.13036 http://scihub22266oqcxt.onion/10.1002/1873-3468.13036 C5969217!5969217!29570778     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Lett 2018 ; 592 (9): 1535-44 Nephropedia Template TP {{tp|p=29570778|t=2018. Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules |pdf=|usr=}}{{29570778}} gab.com Text Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules JO: FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=29570778 #FOAvip Immune cells communicate by releasing large quantities of cytokines. Although the mechanisms of cytokine secretion are increasingly understood, quantitative knowledge of the number of cytokines per vesicle is still lacking. Here, we measured with quantitative microscopy the release rate of vesicles potentially carrying interleukin?6 (IL?6) in human dendritic cells. By comparing this to the total secreted IL?6, we estimate that secretory vesicles contain about 0.5?3 IL?6 molecules, but with a large spread among cells/donors. Moreover, IL?6 did not accumulate within most cells, indicating that synthesis and not trafficking is the bottleneck for IL?6 production. IL?6 accumulated in the Golgi apparatus only in ~ 10% of the cells. Understanding how immune cells produce cytokines is important for designing new immunomodulatory drugs. Twit Text FOAVip Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules ????FEBS Lett http://www.kidney.de/pget.php?&tw=1&pmid=29570778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29570778 #FOAvip English Wikipedia <ref>{{Cite pmid|29570778}}</ref> Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules #MMPMID29570778 Verboogen DRJ; ter Beest M; Honigmann A; van den Bogaart G FEBS Lett 2018[May]; 592 (9): 1535-44 PMID29570778show ga Immune cells communicate by releasing large quantities of cytokines. Although the mechanisms of cytokine secretion are increasingly understood, quantitative knowledge of the number of cytokines per vesicle is still lacking. Here, we measured with quantitative microscopy the release rate of vesicles potentially carrying interleukin?6 (IL?6) in human dendritic cells. By comparing this to the total secreted IL?6, we estimate that secretory vesicles contain about 0.5?3 IL?6 molecules, but with a large spread among cells/donors. Moreover, IL?6 did not accumulate within most cells, indicating that synthesis and not trafficking is the bottleneck for IL?6 production. IL?6 accumulated in the Golgi apparatus only in ~ 10% of the cells. Understanding how immune cells produce cytokines is important for designing new immunomodulatory drugs. äSecretory vesicles of immune cells contain only a limited number of in(epmc).pdf DeepDyve Pubget Overpricing