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Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Alzheimers+Res+Ther 2018 ; 10 (ä): ä Nephropedia Template TP
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Effects of lifetime cumulative ginseng intake on cognitive function in late life #MMPMID29793529
Lho SK; Kim TH; Kwak KP; Kim K; Kim BJ; Kim SG; Kim JL; Kim TH; Moon SW; Park JY; Park JH; Byun S; Suh SW; Seo JY; So Y; Ryu SH; Youn JC; Lee KH; Lee DY; Lee DW; Lee SB; Lee JJ; Lee JR; Jeong H; Jeong HG; Jhoo JH; Han K; Hong JW; Han JW; Kim KW
Alzheimers Res Ther 2018[]; 10 (ä): ä PMID29793529show ga
Background: We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort of Korean elders. Methods: Community-dwelling elders (N?=?6422; mean age?=?70.2?±?6.9 years, education?=?8.0?±?5.3 years, female?=?56.8%) from the Korean Longitudinal Study on Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed the 2-year and 4-year follow-up evaluations. Subjects were categorized according to cumulative ginseng intake at baseline evaluation; no use group, low use (5 years) group, and high use (??5 years) group. One-way analysis of covariance (ANCOVA) was conducted to compare the impact of cumulative ginseng intake on baseline Consortium to Establish a Registry for Alzheimer?s Disease Assessment Packet neuropsychological battery total score (CERAD total score) and Mini-Mental State Examination (MMSE) score among the three groups while adjusting for potential covariates. A repeated-measures ANCOVA was performed to investigate the impacts on the changes in CERAD total scores and MMSE scores during the 4 years of follow-up. Results: The high use group showed higher CERAD total scores compared to the no use group after controlling for age, sex, education years, socioeconomic status, smoking, alcohol intake, presence of hypertension, stroke history, Geriatric Depression Scale, Cumulative Illness Rating Scale, and presence of the APOE e4 allele (F(2, 4762)?=?3.978, p?=?0.019). The changes of CERAD total score for 2 or 4 years of follow-up did not differ according to the use of ginseng. Conclusions: Cumulative ginseng use for longer than 5 years may be beneficial to cognitive function in late life. Electronic supplementary material: The online version of this article (10.1186/s13195-018-0380-0) contains supplementary material, which is available to authorized users.