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10.1186/s12964-018-0236-z

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C5968562!5968562!29793495
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suck abstract from ncbi


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pmid29793495      Cell+Commun+Signal 2018 ; 16 (ä): ä
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  • Casein kinase 1?: biological mechanisms and theranostic potential #MMPMID29793495
  • Jiang S; Zhang M; Sun J; Yang X
  • Cell Commun Signal 2018[]; 16 (ä): ä PMID29793495show ga
  • Casein kinase 1? (CK1?) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1? is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1?, and provide an overview of existing challenges and potential opportunities for advancing theranostics.
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