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10.1159/000486322 http://scihub22266oqcxt.onion/10.1159/000486322 C5968261!5968261!29849535     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephron+Extra 2018 ; 8 (1): 1-10 Nephropedia Template TP {{tp|p=29849535|t=2018. Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection |pdf=|usr=}}{{29849535}} gab.com Text Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection JO: Nephron Extra http://www.kidney.de/pget.php?&tw=1&pmid=29849535 #FOAvip Purpose: Human infection with Dobrava-Belgrade virus (DOBV) in Northern Germany causes a mild form of hantavirus disease predominantly characterized by acute kidney injury due to interstitial nephritis. We evaluated the largest number of DOBV-infected patients so far regarding clinical course, proteinuria, and prognostic markers. Patients and Methods: Patients with DOBV-associated hantavirus disease admitted to the Renal Division of the University of Lübeck (Germany) between 1997 and 2012 were included in this study. Symptoms, clinical course, laboratory parameters, and urinary protein analysis were investigated at admission (baseline, t0), 3?5 days (t3?5), 10?17 days (t10?17), and after 1 year of follow-up (t365). Results: Of the 34 patients (male/female ratio: 23/11; age: 41 ± 14 years) included in the study, 4 underwent hemodialysis (HD). Glomerular filtration rate was 17 ± 14 mL/min at t0 and increased to 27 ± 26 mL/min (t3?5), 57 ± 20 mL/min (t10?17), and 84 ± 16 mL/min (t365). Albuminuria and tubular proteinuria (?1- and ?2-microglobulin) decreased during follow-up; the urinary ?1-microglobulin concentration in patients who required HD was significantly higher than that in patients not requiring HD (t0: 186 ± 51 vs. 45 ± 26 mg/g creatinine; t3?5: 87 ± 14 vs. 32 ± 16 mg/g creatinine; t10?17: 63 ± 18 vs. 28 ± 12 mg/g creatinine; p < 0.001). Conclusions: DOBV infection of inpatients in Northern Germany is associated with severe kidney injury that recovers within a few weeks and normalizes within 1 year. Tubular proteinuria is associated with the severity of kidney injury and the necessity of renal replacement therapy in these DOBV-infected patients. Twit Text FOAVip Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection ????Nephron Extra http://www.kidney.de/pget.php?&tw=1&pmid=29849535 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29849535 #FOAvip English Wikipedia <ref>{{Cite pmid|29849535}}</ref> Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection #MMPMID29849535 Meier M; Kramer J; Jabs WJ; Nolte C; Hofmann J; Krüger DH; Lehnert H; Nitschke M Nephron Extra 2018[Jan]; 8 (1): 1-10 PMID29849535show ga Purpose: Human infection with Dobrava-Belgrade virus (DOBV) in Northern Germany causes a mild form of hantavirus disease predominantly characterized by acute kidney injury due to interstitial nephritis. We evaluated the largest number of DOBV-infected patients so far regarding clinical course, proteinuria, and prognostic markers. Patients and Methods: Patients with DOBV-associated hantavirus disease admitted to the Renal Division of the University of Lübeck (Germany) between 1997 and 2012 were included in this study. Symptoms, clinical course, laboratory parameters, and urinary protein analysis were investigated at admission (baseline, t0), 3?5 days (t3?5), 10?17 days (t10?17), and after 1 year of follow-up (t365). Results: Of the 34 patients (male/female ratio: 23/11; age: 41 ± 14 years) included in the study, 4 underwent hemodialysis (HD). Glomerular filtration rate was 17 ± 14 mL/min at t0 and increased to 27 ± 26 mL/min (t3?5), 57 ± 20 mL/min (t10?17), and 84 ± 16 mL/min (t365). Albuminuria and tubular proteinuria (?1- and ?2-microglobulin) decreased during follow-up; the urinary ?1-microglobulin concentration in patients who required HD was significantly higher than that in patients not requiring HD (t0: 186 ± 51 vs. 45 ± 26 mg/g creatinine; t3?5: 87 ± 14 vs. 32 ± 16 mg/g creatinine; t10?17: 63 ± 18 vs. 28 ± 12 mg/g creatinine; p < 0.001). Conclusions: DOBV infection of inpatients in Northern Germany is associated with severe kidney injury that recovers within a few weeks and normalizes within 1 year. Tubular proteinuria is associated with the severity of kidney injury and the necessity of renal replacement therapy in these DOBV-infected patients. äProteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Inf(epmc).pdf DeepDyve Pubget Overpricing