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The Relationship between Hypomagnesemia and Pulmonary Function Tests in Patients
with Chronic Asthma
#MMPMID29455196
K?l?c H
; Kanbay A
; Karalezl? A
; Babaoglu E
; Hasanoglu HC
; Erel O
; Ates C
Med Princ Pract
2018[]; 27
(2
): 139-144
PMID29455196
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OBJECTIVE: To investigate the relationship between serum values of magnesium and
the parameters of the pulmonary function tests (PFT) in patients with chronic
asthma. SUBJECTS AND METHODS: This study recruited 50 patients with chronic
stable asthma and 40 healthy individuals as a control group. Data on age, sex,
severity of asthma, PFT, and details of drug therapy were obtained from each
group. Serum magnesium, potassium, phosphorus, calcium, and sodium levels were
also measured. To evaluate differences between groups, the Student t test or
Mann-Whitney U test was performed for continuous variables, and the ?2 test for
categorical variables. RESULTS: In the asthma group, 10% (n = 9) of the patients
had hypomagnesemia and 5.5% (n = 5) had hypophosphatemia. Patients with asthma
were divided into two groups: the hypomagnesemic group (n = 9) and the
normomagnesemic group (n = 41). Forced expiratory volume in 1 s (FEV1), FEV1%,
peak expiratory flow (PEF), and PEF% were lower in the hypomagnesemic group than
in the normomagnesemic group (p = 0.02). Multiple logistic regression analysis
revealed a statistically significant association between hypomagnesemia and PFT
in the hypomagnesemic asthmatic group. The correlations of age with FEV1, FEV1%,
PEF, and PEF% were as follows: p = 0.00, r = 0.29; p = 0.00, r = 0.43; p = 0.03,
r = 0.22; p = 0.00, r = 0.38; and p = 0.03, r = 0.22, respectively. The
correlation of serum magnesium levels with PFT (FEV1, FEV1%, PEF, PEF%) were as
follows: p = 0.001, r = 0.29; p = 0.001, r = 0.43; p = 0.03, r = 0.22; and p =
0.001, r = 0.38, respectively. The other electrolytes were within the normal
range in both groups. CONCLUSION: In this study, hypomagnesemia and
hypophosphatemia were found to be the most common electrolyte abnormalities in
patients with chronic stable asthma. FEV1, FEV1%, PEF, and PEF% were
significantly lower in asthmatic patients with hypomagnesemia compared to
asthmatic patients with normomagnesemia.
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