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10.1038/s41389-018-0053-7 http://scihub22266oqcxt.onion/10.1038/s41389-018-0053-7 C5968032!5968032 !29795364     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29795364 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oncogenesis 2018 ; 7 (5 ): 43 Nephropedia Template TP {{tp|p=29795364 |t=2018. AIRE promotes androgen-independent prostate cancer by directly regulating IL-6 and modulating tumor microenvironment |pdf=|usr=}}{{29795364 }} gab.com Text AIRE promotes androgen-independent prostate cancer by directly regulating IL-6 and modulating tumor microenvironment JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29795364 #FOAvip Early stage prostate cancers are dependent on androgens for their growth and survival and androgen withdrawal causes them to regress. Progressive prostate cancers eventually acquire androgen independence rendering anti-androgen therapy ineffective. However, the factors leading to this have not been adequately addressed. This study shows that AIRE finds differential expression in androgen-dependent and -independent prostate cancer cells. AIRE expression is more in androgen-independent cells due to its regulation by transcription factor Elk-1. These enhanced levels of AIRE modulate the prostate tumor microenvironment by transcriptionally activating a malignancy gene IL-6 in androgen-independent cells. Additionally, AIRE prevents the cancer cells from anticancer drug-induced death and enhances their invasiveness. Moreover, AIRE by modulating the cytokine milieu skews the tumor-associated macrophage polarization towards M2 phenotype with increased CD206 and CD163 expression. Subcutaneous mouse model of prostate cancer revealed AIRE(+/+) mice forming a palpable tumor and presents lymphadenopathy however, only a small benign tumor is observed in AIRE(-/-) mice and lymph nodes appear normal in size. In conclusion, our findings suggest AIRE as a probable factor in promoting prostate cancer progression. Twit Text FOAVip AIRE promotes androgen-independent prostate cancer by directly regulating IL-6 and modulating tumor microenvironment ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29795364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29795364 #FOAvip English Wikipedia <ref>{{Cite pmid|29795364 }}</ref> AIRE promotes androgen-independent prostate cancer by directly regulating IL-6 and modulating tumor microenvironment #MMPMID29795364 Kalra R ; Bhagyaraj E ; Tiwari D ; Nanduri R ; Chacko AP ; Jain M ; Mahajan S ; Khatri N ; Gupta P Oncogenesis 2018[May]; 7 (5 ): 43 PMID29795364 show ga Early stage prostate cancers are dependent on androgens for their growth and survival and androgen withdrawal causes them to regress. Progressive prostate cancers eventually acquire androgen independence rendering anti-androgen therapy ineffective. However, the factors leading to this have not been adequately addressed. This study shows that AIRE finds differential expression in androgen-dependent and -independent prostate cancer cells. AIRE expression is more in androgen-independent cells due to its regulation by transcription factor Elk-1. These enhanced levels of AIRE modulate the prostate tumor microenvironment by transcriptionally activating a malignancy gene IL-6 in androgen-independent cells. Additionally, AIRE prevents the cancer cells from anticancer drug-induced death and enhances their invasiveness. Moreover, AIRE by modulating the cytokine milieu skews the tumor-associated macrophage polarization towards M2 phenotype with increased CD206 and CD163 expression. Subcutaneous mouse model of prostate cancer revealed AIRE(+/+) mice forming a palpable tumor and presents lymphadenopathy however, only a small benign tumor is observed in AIRE(-/-) mice and lymph nodes appear normal in size. In conclusion, our findings suggest AIRE as a probable factor in promoting prostate cancer progression. ?AIRE promotes androgen-independent prostate cancer by directly regulat(epmc).pdf DeepDyve Pubget Overpricing