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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Metab 2013 ; 17 (4): 491-506 Nephropedia Template TP
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Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure #MMPMID23562075
Liesa M; Shirihai OS
Cell Metab 2013[Apr]; 17 (4): 491-506 PMID23562075show ga
Mitochondrial fusion, fission and mitophagy form an essential axis of mitochondrial quality control. However, quality control may not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placing bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics may provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.