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10.1016/j.cmet.2013.03.002

http://scihub22266oqcxt.onion/10.1016/j.cmet.2013.03.002
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C5967396!5967396!23562075
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suck abstract from ncbi


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pmid23562075      Cell+Metab 2013 ; 17 (4): 491-506
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  • Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure #MMPMID23562075
  • Liesa M; Shirihai OS
  • Cell Metab 2013[Apr]; 17 (4): 491-506 PMID23562075show ga
  • Mitochondrial fusion, fission and mitophagy form an essential axis of mitochondrial quality control. However, quality control may not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placing bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics may provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.
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