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10.1038/s41419-018-0657-z http://scihub22266oqcxt.onion/10.1038/s41419-018-0657-z C5967338!5967338 !29795373     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29795373 &cmd=llinks): Failed to open stream: HTTP request failed! 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Gamma synuclein is a novel Twist1 target that promotes TGF-?-induced cancer cell migration and invasion |pdf=|usr=}}{{29795373 }} gab.com Text Gamma synuclein is a novel Twist1 target that promotes TGF- -induced cancer cell migration and invasion JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29795373 #FOAvip Transforming growth factor ? (TGF-?) is critical for embryonic development, adult tissue homeostasis, and tumor progression. TGF-? suppresses tumors at early stage, but promotes metastasis at later stage through oncogenes such as Twist1. Gamma-synuclein (SNCG) is overexpressed in a variety of invasive and metastatic cancer. Here, we show that TGF-? induces SNCG expression by Smad-Twist1 axis, thus promoting TGF-?- and Twist1-induced cancer cell migration and invasion. We identify multiple Twist1-binding sites (E-boxes) in SNCG promoter. Chromatin immunoprecipitation and luciferase assays confirm the binding of Twist1 to the E-boxes of SNCG promoter sequence (-129/-1026?bp). Importantly, the Twist1-binding site close to the transcription initiation site is critical for the upregulation of SNCG expression by TGF-? and Twist1. Mutations of Twist1 motif on the SNCG promoter constructs markedly reduces the promoter activity. We further show that TGF-? induces Twist1 expression through Smad thereby enhancing the binding of Twist1 to SNCG promoter, upregulating SNCG promoter activity and increasing SNCG expression. SNCG knockdown abrogates TGF-?- or Twist1-induced cancer cell migration and invasion. Finally, SNCG knockdown inhibits the promotion of cancer metastasis by Twist1. Together, our data demonstrate that SNCG is a novel target of TGF-?-Smad-Twist1 axis and a mediator of Twist1-induced cancer metastasis. Twit Text FOAVip Gamma synuclein is a novel Twist1 target that promotes TGF- -induced cancer cell migration and invasion ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29795373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29795373 #FOAvip English Wikipedia <ref>{{Cite pmid|29795373 }}</ref> Gamma synuclein is a novel Twist1 target that promotes TGF-?-induced cancer cell migration and invasion #MMPMID29795373 Shao T ; Song P ; Hua H ; Zhang H ; Sun X ; Kong Q ; Wang J ; Luo T ; Jiang Y Cell Death Dis 2018[May]; 9 (6 ): 625 PMID29795373 show ga Transforming growth factor ? (TGF-?) is critical for embryonic development, adult tissue homeostasis, and tumor progression. TGF-? suppresses tumors at early stage, but promotes metastasis at later stage through oncogenes such as Twist1. Gamma-synuclein (SNCG) is overexpressed in a variety of invasive and metastatic cancer. Here, we show that TGF-? induces SNCG expression by Smad-Twist1 axis, thus promoting TGF-?- and Twist1-induced cancer cell migration and invasion. We identify multiple Twist1-binding sites (E-boxes) in SNCG promoter. Chromatin immunoprecipitation and luciferase assays confirm the binding of Twist1 to the E-boxes of SNCG promoter sequence (-129/-1026?bp). Importantly, the Twist1-binding site close to the transcription initiation site is critical for the upregulation of SNCG expression by TGF-? and Twist1. Mutations of Twist1 motif on the SNCG promoter constructs markedly reduces the promoter activity. We further show that TGF-? induces Twist1 expression through Smad thereby enhancing the binding of Twist1 to SNCG promoter, upregulating SNCG promoter activity and increasing SNCG expression. SNCG knockdown abrogates TGF-?- or Twist1-induced cancer cell migration and invasion. Finally, SNCG knockdown inhibits the promotion of cancer metastasis by Twist1. Together, our data demonstrate that SNCG is a novel target of TGF-?-Smad-Twist1 axis and a mediator of Twist1-induced cancer metastasis. |*Cell Movement [MESH] |E-Box Elements [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |HeLa Cells [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Nuclear Proteins/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Smad Proteins/metabolism [MESH] |Transforming Growth Factor beta/*pharmacology [MESH] |Twist-Related Protein 1/*metabolism [MESH] |Up-Regulation/drug effects [MESH]Gamma synuclein is a novel Twist1 target that promotes TGF-?-induced c(epmc).pdf DeepDyve Pubget Overpricing