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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Neurol
2018 ; 18
(1
): 72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Anti-ganglioside complex antibody profiles in a recurrent complicated case of
GQ1b-seronegative miller fisher syndrome and Bickerstaff brainstem encephalitis:
a case report
#MMPMID29792178
Ito H
; Hatanaka Y
; Fukami Y
; Harada Y
; Kobayashi R
; Okada H
; Uchibori A
; Chiba A
; Okuda S
BMC Neurol
2018[May]; 18
(1
): 72
PMID29792178
show ga
BACKGROUND: Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS) and
Bickerstaff brainstem encephalitis (BBE) are a group of autoimmune neurological
disorders (GBS spectrum disorder) that rarely recur. Recently, anti-ganglioside
complex antibodies (GSC-Abs) were identified in patients with GBS spectrum
disorder. However, there has been no case report describing GSC-Abs profiles in a
recurrent case showing different phenotypes. CASE PRESENTATION: We report the
case of a 33-year-old male patient with GQ1b-seronegative BBE-GBS after two prior
episodes of MFS-GBS. Our patient showed ophthalmoplegia, ataxia, areflexia and a
weakness of the extremities (MFS and GBS symptoms) in all episodes. In the
episode reported here, our patient showed disturbed consciousness and an extensor
response to cutaneous plantar stimulation was observed (BBE symptoms), with
severe disability and requirement for artificial respiration management. GSC-Abs
detected in previous episodes were also detected in the subsequent episodes,
while new GSC-Abs emerged in each episode. Interestingly, whereas antibodies to
GA1/GQ1b and GA1/GT1a, which are commonly identified in patients with GBS, MFS or
BBE, appeared in all episodes, antibodies to GD1a/GD1b and GD1b/GT1b, which are
predominantly associated with severe disability and the requirement for
artificial respiration management in GBS, emerged for the first time in this
episode. CONCLUSION: This study reports novel phenomena about the GSC-Abs
profiles and its relationship with clinical features in a case with recurrent GBS
spectrum disorder, showing different phenotypes in different episodes. Further
studies are required to reveal the significance of the GSC-Abs profiles in
recurrent GBS spectrum disorder.