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10.1155/2018/9562803

http://scihub22266oqcxt.onion/10.1155/2018/9562803
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C5966667!5966667!29854826
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suck abstract from ncbi


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pmid29854826      J+Vet+Med 2018 ; 2018 (ä): ä
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  • Suspected Lonely Mouse Syndrome as a Cage Effect in a Drug Safety Study #MMPMID29854826
  • Ye X; Itzoe M; Sarabia-Estrada R; DeTolla L; Tyler BM; Guarnieri M
  • J Vet Med 2018[]; 2018 (ä): ä PMID29854826show ga
  • Studies have demonstrated that buprenorphine, a front line drug for veterinary analgesia, may alleviate symptoms of chronic pain. A cage side observation protocol was used to record behavioral signs in a mouse clinical trial of extended release buprenorphine. A retrospective review of the observations for signs of pain and stress revealed that mice given a fivefold overdose of buprenorphine (16.25?mg/kg) showed lethargy and facial signs associated with stress. However, similar signs were observed in the drug-free control mice as early as Day 3 of single-cage housing. This appears to be the first report of cage effects in a clinical trial for a veterinary drug.
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