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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP
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TGF-? concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration #MMPMID29795291
Tosi GM; Neri G; Caldi E; Fusco F; Bacci T; Tarantello A; Nuti E; Marigliani D; Baiocchi S; Traversi C; Barbarino M; Eandi CM; Parolini B; Mundo L; Santucci A; Orlandini M; Galvagni F
Sci Rep 2018[]; 8 (ä): ä PMID29795291show ga
Controversy still exists regarding the role of the TGF-? in neovascular age-related macular degeneration (nAMD), a major cause of severe visual loss in the elderly in developed countries. Here, we measured the concentrations of active TGF-?1, TGF-?2, and TGF-?3 by ELISA in the aqueous humor of 20 patients affected by nAMD, who received 3 consecutive monthly intravitreal injections of anti-VEGF-A antibody. Samples were collected at baseline (before the first injection), month 1 (before the second injection), and month 2 (before the third injection). The same samples were used in a luciferase-based reporter assay to test the TGF-? pathway activation. Active TGF-?1 concentrations in the aqueous humor were below the minimum detectable dose. Active TGF-?2 concentrations were significantly lower at baseline and at month 1, compared to controls. No significant differences in active TGF-?3 concentration were found among the sample groups. Moreover, TGF-? pathway activation was significantly lower at baseline compared to controls. Our data corroborate an anti-angiogenic role for TGF-?2 in nAMD. This should be considered from the perspective of a therapy using TGF-? inhibitors.