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10.1038/s41598-018-26442-0 http://scihub22266oqcxt.onion/10.1038/s41598-018-26442-0 C5966430!5966430 !29795291     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29795291 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 8053 Nephropedia Template TP {{tp|p=29795291 |t=2018. TGF-? concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration |pdf=|usr=}}{{29795291 }} gab.com Text TGF- concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29795291 #FOAvip Controversy still exists regarding the role of the TGF-? in neovascular age-related macular degeneration (nAMD), a major cause of severe visual loss in the elderly in developed countries. Here, we measured the concentrations of active TGF-?1, TGF-?2, and TGF-?3 by ELISA in the aqueous humor of 20 patients affected by nAMD, who received 3 consecutive monthly intravitreal injections of anti-VEGF-A antibody. Samples were collected at baseline (before the first injection), month 1 (before the second injection), and month 2 (before the third injection). The same samples were used in a luciferase-based reporter assay to test the TGF-? pathway activation. Active TGF-?1 concentrations in the aqueous humor were below the minimum detectable dose. Active TGF-?2 concentrations were significantly lower at baseline and at month 1, compared to controls. No significant differences in active TGF-?3 concentration were found among the sample groups. Moreover, TGF-? pathway activation was significantly lower at baseline compared to controls. Our data corroborate an anti-angiogenic role for TGF-?2 in nAMD. This should be considered from the perspective of a therapy using TGF-? inhibitors. Twit Text FOAVip TGF- concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29795291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29795291 #FOAvip English Wikipedia <ref>{{Cite pmid|29795291 }}</ref> TGF-? concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration #MMPMID29795291 Tosi GM ; Neri G ; Caldi E ; Fusco F ; Bacci T ; Tarantello A ; Nuti E ; Marigliani D ; Baiocchi S ; Traversi C ; Barbarino M ; Eandi CM ; Parolini B ; Mundo L ; Santucci A ; Orlandini M ; Galvagni F Sci Rep 2018[May]; 8 (1 ): 8053 PMID29795291 show ga Controversy still exists regarding the role of the TGF-? in neovascular age-related macular degeneration (nAMD), a major cause of severe visual loss in the elderly in developed countries. Here, we measured the concentrations of active TGF-?1, TGF-?2, and TGF-?3 by ELISA in the aqueous humor of 20 patients affected by nAMD, who received 3 consecutive monthly intravitreal injections of anti-VEGF-A antibody. Samples were collected at baseline (before the first injection), month 1 (before the second injection), and month 2 (before the third injection). The same samples were used in a luciferase-based reporter assay to test the TGF-? pathway activation. Active TGF-?1 concentrations in the aqueous humor were below the minimum detectable dose. Active TGF-?2 concentrations were significantly lower at baseline and at month 1, compared to controls. No significant differences in active TGF-?3 concentration were found among the sample groups. Moreover, TGF-? pathway activation was significantly lower at baseline compared to controls. Our data corroborate an anti-angiogenic role for TGF-?2 in nAMD. This should be considered from the perspective of a therapy using TGF-? inhibitors. |Aged [MESH] |Angiogenesis Inhibitors/administration & dosage/pharmacology [MESH] |Aqueous Humor/drug effects/*metabolism [MESH] |Case-Control Studies [MESH] |Down-Regulation [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Intravitreal Injections [MESH] |Macular Degeneration/drug therapy/*metabolism/pathology [MESH] |Male [MESH] |Neovascularization, Pathologic/drug therapy/*metabolism/pathology [MESH] |Ranibizumab/administration & dosage/*pharmacology [MESH] |Transforming Growth Factor beta1/*metabolism [MESH] |Transforming Growth Factor beta2/*metabolism [MESH] |Transforming Growth Factor beta3/*metabolism [MESH]TGF-? concentrations and activity are down-regulated in the aqueous hu(epmc).pdf DeepDyve Pubget Overpricing