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10.1038/s41389-018-0050-x http://scihub22266oqcxt.onion/10.1038/s41389-018-0050-x C5966388!5966388!29795279     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2018 ; 7 (5): ä Nephropedia Template TP {{tp|p=29795279|t=2018. Dysregulation of the MiR-449b target TGFBI alters the TGF? pathway to induce cisplatin resistance in nasopharyngeal carcinoma |pdf=|usr=}}{{29795279}} gab.com Text Dysregulation of the MiR-449b target TGFBI alters the TGF pathway to induce cisplatin resistance in nasopharyngeal carcinoma JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29795279 #FOAvip Despite the improvement in locoregional control of nasopharyngeal carcinoma (NPC), distant metastasis (DM), and chemoresistance persist as major causes of mortality. This study identified a novel role for miR-449b, an overexpressed gene in a validated four-miRNA signature for NPC DM, leading to chemoresistance via the direct targeting of transforming growth factor beta-induced (TGFBI). In vitro shRNA-mediated downregulation of TGFBI induced phosphorylation of PTEN and AKT, increasing cisplatin resistance. Conversely, the overexpression of TGFBI sensitized the NPC cells to cisplatin. In NPC patients treated with concurrent chemoradiotherapy (CRT), the overall survival (OS) was significantly inversely correlated with miR-449b, and directly correlated with both TGFBI mRNA and protein expression, as assessed by RNA sequencing and immunohistochemistry (IHC). Mechanistically, co-immunoprecipitation demonstrated that TGFBI competes with pro-TGF?1 for integrin receptor binding. Decreased TGFBI led to increased pro-TGF?1 activation and TGF?1 canonical/noncanonical pathway-induced cisplatin resistance. Thus, overexpression of miR-449b decreases TGFBI, thereby altering the balance between TGFBI and pro-TGF?1, revealing a novel mechanism of chemoresistance in NPC. Twit Text FOAVip Dysregulation of the MiR-449b target TGFBI alters the TGF pathway to induce cisplatin resistance in nasopharyngeal carcinoma ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=29795279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29795279 #FOAvip English Wikipedia <ref>{{Cite pmid|29795279}}</ref> Dysregulation of the MiR-449b target TGFBI alters the TGF? pathway to induce cisplatin resistance in nasopharyngeal carcinoma #MMPMID29795279 Bissey PA; Law JH; Bruce JP; Shi W; Renoult A; Chua MLK; Yip KW; Liu FF Oncogenesis 2018[May]; 7 (5): ä PMID29795279show ga Despite the improvement in locoregional control of nasopharyngeal carcinoma (NPC), distant metastasis (DM), and chemoresistance persist as major causes of mortality. This study identified a novel role for miR-449b, an overexpressed gene in a validated four-miRNA signature for NPC DM, leading to chemoresistance via the direct targeting of transforming growth factor beta-induced (TGFBI). In vitro shRNA-mediated downregulation of TGFBI induced phosphorylation of PTEN and AKT, increasing cisplatin resistance. Conversely, the overexpression of TGFBI sensitized the NPC cells to cisplatin. In NPC patients treated with concurrent chemoradiotherapy (CRT), the overall survival (OS) was significantly inversely correlated with miR-449b, and directly correlated with both TGFBI mRNA and protein expression, as assessed by RNA sequencing and immunohistochemistry (IHC). Mechanistically, co-immunoprecipitation demonstrated that TGFBI competes with pro-TGF?1 for integrin receptor binding. Decreased TGFBI led to increased pro-TGF?1 activation and TGF?1 canonical/noncanonical pathway-induced cisplatin resistance. Thus, overexpression of miR-449b decreases TGFBI, thereby altering the balance between TGFBI and pro-TGF?1, revealing a novel mechanism of chemoresistance in NPC. äDysregulation of the MiR-449b target TGFBI alters the TGF? pathway to (epmc).pdf DeepDyve Pubget Overpricing