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2018 ; 9
(36
): 24283-24290
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Clinical characteristics and diagnosis of a rare case of systemic AL amyloidosis:
a descriptive study
#MMPMID29849940
Chen P
; Wang Z
; Liu H
; Liu D
; Gong Z
; Qi J
; Hu J
Oncotarget
2018[May]; 9
(36
): 24283-24290
PMID29849940
show ga
Systemic amyloidosis is a rare disease involving multiple organs. It is difficult
to establish diagnosis as the symptoms is diverse and non-specific. And without
specific therapy the prognosis is very poor. We analyzed detailed clinical and
laboratorial data of a 53-year-old male patient. The characteristic features
included refractory pleural effusion, extraordinary hepatomegaly and cardiac
failure. The illness lasted 9 months and therapy period spanned 4 months. Fine
needle biopsy of liver, lung, heart, pancreas and kidney was performed.
Immunohistochemistry, immunofluorescence, Congo staining and hematoxylin and
eosin staining were performed. All specimens were stained pink with haematoxylin
and eosin staining. Amorphous deposits of eosinophilic material were visible
within the Congo red dye stained liver tissue whereas under cross-polarized light
pathognomonic apple-green birefringence of amyloid deposits was visible. At last
systemic AL amyloidosis diagnosis was confirmed. The report showed an unusual AL
amyloidosis case in detail which would be helpful for physician in clinical work.