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2017 ; 3
(ä): 2059513117695659
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The development and impact of heterotopic ossification in burns: a review of four
decades of research
#MMPMID29799559
Kornhaber R
; Foster N
; Edgar D
; Visentin D
; Ofir E
; Haik J
; Harats M
Scars Burn Heal
2017[Jan]; 3
(ä): 2059513117695659
PMID29799559
show ga
INTRODUCTION: Heterotopic ossification (HO) is the formation of lamellar bone
within connective and other tissue where bone should not form and is a rare
complication after burn injury. However, it leads to severe pain and distress,
marked reduction in joint range of motion (ROM), impaired function and increased
hospital length of stay. The pathophysiology, incidence and risk factors of HO
remain poorly understood in burns and other traumas and the management,
controversial. The aim of this comprehensive review, therefore, was to synthesise
the available evidence on the development and treatment of HO after acute burn
injury. METHODS: The review was based on a systematic search of five electronic
databases PubMed, EMBASE, CINAHL, LILACS and Scopus. RESULTS: Synthesis and
analysis of the data highlighted that, despite the passage of time, little
translatable evidence is available to guide any prevention, screening, diagnostic
or pharmacological or physical management protocols. DISCUSSION: Causes of HO
remain confounded, therefore prevention is difficult. Although spontaneous
resolution is possible, surgical resection remains the recommended treatment when
ROM and activities of daily living are severely affected. CONCLUSION: The
findings from this review indicate that multicentre data pooling is needed to
understand the optimum pathway to prevention, identification and treatment of HO
in acute burn patients.