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2016 ; 2
(ä): 2059513116676828
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The effects of advanced glycation end products (AGEs) on dermal wound healing and
scar formation: a systematic review
#MMPMID29799552
Van Putte L
; De Schrijver S
; Moortgat P
Scars Burn Heal
2016[Jan]; 2
(ä): 2059513116676828
PMID29799552
show ga
INTRODUCTION: With ageing, the skin gradually loses its youthful appearance and
functions like wound healing and scar formation. The pathophysiological theory of
Advanced Glycation End products (AGEs) has gained traction during the last
decade. This review aims to document the influence of AGEs on the mechanical and
physiologic properties of the skin, how they affect dermal wound healing and scar
formation in high-AGE populations like elderly patients and diabetics, and
potential therapeutic strategies. METHODS: This systematic literature study
involved a structured search in Pubmed and Web of Science with qualitative
analysis of 14 articles after a three-staged selection process with the use of
in- and exclusion criteria. RESULTS: Overall, AGEs cause shortened, thinned, and
disorganized collagen fibrils, consequently reducing elasticity and skin/scar
thickness with increased contraction and delayed wound closure. Documented
therapeutic strategies include dietary AGE restriction, sRAGE decoy receptors,
aminoguanidine, RAGE-blocking antibodies, targeted therapy, thymosin ?4,
anti-oxidant agents and gold nanoparticles, ethyl pyruvate, Gal-3 manipulation
and metformin. DISCUSSION: With lack of evidence concerning scars, no definitive
conclusions can yet be made about the role of AGEs on possible appearance or
function of scar tissue. However, all results suggest that scars tend to be more
rigid and contractile with persistent redness and reduced tendency towards
hypertrophy as AGEs accumulate. CONCLUSION: Abundant evidence supports the
pathologic role of AGEs in ageing and dermal wound healing and the effectiveness
of possible therapeutic agents. More research is required to conclude its role in
scar formation and scar therapy.