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10.5811/cpcem.2017.6.34356

http://scihub22266oqcxt.onion/10.5811/cpcem.2017.6.34356
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C5965212!5965212!29849330
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suck abstract from ncbi


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pmid29849330      Clin+Pract+Cases+Emerg+Med 2017 ; 1 (4): 349-53
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  • Reversal of Dabigatran with Idarucizumab in Acute Subarachnoid Hemorrhage #MMPMID29849330
  • Balakumar J; Santiago R; Supino M
  • Clin Pract Cases Emerg Med 2017[Nov]; 1 (4): 349-53 PMID29849330show ga
  • Dabigatran etexilate mesylate is a direct thrombin inhibitor used for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. Dabigatran belongs to a new generation of oral agents for anticoagulation ? the direct oral anticoagulants (DOACs). The DOACs also include the factor Xa inhibitors rivaroxaban, apixaban, and edoxaban. In the case of major or life-threatening bleeding and/or the need for emergent invasive procedures, a reversal agent is needed if a patient is taking one of these medications. Research has shown the efficacy of idarucizumab as an antidote in healthy volunteers, but data in the case of life-threatening bleeds remains limited. We report a case of a patient who suffered a traumatic subarachnoid hemorrhage and received effective treatment with idarucizumab. Along with other reports, our case demonstrates that dabigatran-related major and/or life-threatening bleeds may be effectively counteracted by idarucizumab. This provides an option to emergency department providers in managing clinically significant bleeds in patients taking dabigatran.
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