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10.1182/bloodadvances.2017015479 http://scihub22266oqcxt.onion/10.1182/bloodadvances.2017015479 C5965050!5965050 !29752284     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29752284 &cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of the thrombotic and fibrinolytic activities of tumor cell-derived extracellular vesicles |pdf=|usr=}}{{29752284 }} gab.com Text Analysis of the thrombotic and fibrinolytic activities of tumor cell-derived extracellular vesicles JO: Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=29752284 #FOAvip Exosomes and microvesicles (MVs) are small extracellular vesicles secreted by tumor cells and are suggested to contribute to the thrombotic events that commonly occur in patients with advanced malignancies. Paradoxically, these vesicles have been reported to also possess fibrinolytic activity. To determine whether thrombotic or fibrinolytic activity is a predominant characteristic of these extracellular vesicles, we prepared exosomes and MVs from 2 breast cancer cell lines (MDA-MB-231 and MCF7), a lung cancer cell line (A549), and a leukemia cell line (NB4) and assayed their thrombotic and fibrinolytic activities. We observed that thrombotic activity was a common feature of MVs but not exosomes. Exosomes and/or MVs from several cell lines, with the exception of the A549 cell line, displayed fibrinolytic activity toward a pure fibrin clot, but only exosomes from MDA-MB-231 cells could degrade a fibrin clot formed in plasma. Increasing the malignant potential of MCF7 cells decreased the thrombotic activity of their MVs but did not alter their fibrinolytic activity. Decreasing the malignant potential of NB4 cells did not alter the thrombotic or fibrinolytic activity of their MVs or exosomes. Finally, the incubation of MDA-MB-231 cell-derived exosomes with A549 cells increased plasmin generation by these cells. Our data indicate that MVs generally have thrombotic activity, whereas thrombotic activity is not commonly observed for exosomes. Furthermore, exosomes and MVs generally do not display fibrinolytic activity under physiological conditions. Twit Text FOAVip Analysis of the thrombotic and fibrinolytic activities of tumor cell-derived extracellular vesicles ????Blood Adv http://www.kidney.de/pget.php?&tw=1&pmid=29752284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29752284 #FOAvip English Wikipedia <ref>{{Cite pmid|29752284 }}</ref> Analysis of the thrombotic and fibrinolytic activities of tumor cell-derived extracellular vesicles #MMPMID29752284 Durrieu L ; Bharadwaj A ; Waisman DM Blood Adv 2018[May]; 2 (10 ): 1054-1065 PMID29752284 show ga Exosomes and microvesicles (MVs) are small extracellular vesicles secreted by tumor cells and are suggested to contribute to the thrombotic events that commonly occur in patients with advanced malignancies. Paradoxically, these vesicles have been reported to also possess fibrinolytic activity. To determine whether thrombotic or fibrinolytic activity is a predominant characteristic of these extracellular vesicles, we prepared exosomes and MVs from 2 breast cancer cell lines (MDA-MB-231 and MCF7), a lung cancer cell line (A549), and a leukemia cell line (NB4) and assayed their thrombotic and fibrinolytic activities. We observed that thrombotic activity was a common feature of MVs but not exosomes. Exosomes and/or MVs from several cell lines, with the exception of the A549 cell line, displayed fibrinolytic activity toward a pure fibrin clot, but only exosomes from MDA-MB-231 cells could degrade a fibrin clot formed in plasma. Increasing the malignant potential of MCF7 cells decreased the thrombotic activity of their MVs but did not alter their fibrinolytic activity. Decreasing the malignant potential of NB4 cells did not alter the thrombotic or fibrinolytic activity of their MVs or exosomes. Finally, the incubation of MDA-MB-231 cell-derived exosomes with A549 cells increased plasmin generation by these cells. Our data indicate that MVs generally have thrombotic activity, whereas thrombotic activity is not commonly observed for exosomes. Furthermore, exosomes and MVs generally do not display fibrinolytic activity under physiological conditions. |Breast Neoplasms/*genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Extracellular Vesicles/*metabolism/pathology [MESH] |Female [MESH] |Fibrinolysis/*physiology [MESH] |Humans [MESH] |Microscopy, Electron, Transmission/*methods [MESH]Analysis of the thrombotic and fibrinolytic activities of tumor cell-d(epmc).pdf DeepDyve Pubget Overpricing