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The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in
Systemic Lupus Erythematosus and Lupus Nephritis
#MMPMID29854836
Honarpisheh M
; Köhler P
; von Rauchhaupt E
; Lech M
J Immunol Res
2018[]; 2018
(?): 4126106
PMID29854836
show ga
Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), represent a family of RNA
molecules that do not translate into protein. Nevertheless, they have the ability
to regulate gene expression and play an essential role in immune cell
differentiation and function. MicroRNAs were found to be differentially expressed
in various tissues, and changes in their expression have been associated with
several pathological processes. Yet, their roles in systemic lupus erythematosus
(SLE) and lupus nephritis (LN) remain to be elucidated. Both SLE and LN are
characterized by a complex dysfunction of the innate and adaptive immunity.
Recently, significant findings have been made in understanding SLE through the
use of genetic variant identification and expression pattern analysis and mouse
models, as well as epigenetic analyses. Abnormalities in immune cell responses,
cytokine and chemokine production, cell activation, and apoptosis have been
linked to a unique expression pattern of a number of miRNAs that have been
implicated in the immune pathogenesis of this autoimmune disease. The recent
evidence that significantly increased the understanding of the pathogenesis of
SLE drives a renewed interest in efficient therapy targets. This review aims at
providing an overview of the current state of research on the expression and role
of miRNAs in the immune pathogenesis of SLE and LN.
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