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10.1038/s41467-018-03566-5 http://scihub22266oqcxt.onion/10.1038/s41467-018-03566-5 C5964317!5964317!29581545     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29581545|t=2018. Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction |pdf=|usr=}}{{29581545}} gab.com Text Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29581545 #FOAvip Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to be the result of impaired phagocytosis of synapses by microglia. However, until now the direct phagocytosis of synapses by microglia has not been reported and fundamental questions remain about the precise synaptic structures and phagocytic mechanisms involved. Here we used light sheet fluorescence microscopy to follow microglia?synapse interactions in developing organotypic hippocampal cultures, complemented by a 3D ultrastructural characterization using correlative light and electron microscopy (CLEM). Our findings define a set of dynamic microglia?synapse interactions, including the selective partial phagocytosis, or trogocytosis (trogo-: nibble), of presynaptic structures and the induction of postsynaptic spine head filopodia by microglia. These findings allow us to propose a mechanism for the facilitatory role of microglia in synaptic circuit remodeling and maturation. Twit Text FOAVip Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29581545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29581545 #FOAvip English Wikipedia <ref>{{Cite pmid|29581545}}</ref> Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction #MMPMID29581545 Weinhard L; di Bartolomei G; Bolasco G; Machado P; Schieber NL; Neniskyte U; Exiga M; Vadisiute A; Raggioli A; Schertel A; Schwab Y; Gross CT Nat Commun 2018[]; 9 (ä): ä PMID29581545show ga Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to be the result of impaired phagocytosis of synapses by microglia. However, until now the direct phagocytosis of synapses by microglia has not been reported and fundamental questions remain about the precise synaptic structures and phagocytic mechanisms involved. Here we used light sheet fluorescence microscopy to follow microglia?synapse interactions in developing organotypic hippocampal cultures, complemented by a 3D ultrastructural characterization using correlative light and electron microscopy (CLEM). Our findings define a set of dynamic microglia?synapse interactions, including the selective partial phagocytosis, or trogocytosis (trogo-: nibble), of presynaptic structures and the induction of postsynaptic spine head filopodia by microglia. These findings allow us to propose a mechanism for the facilitatory role of microglia in synaptic circuit remodeling and maturation. äMicroglia remodel synapses by presynaptic trogocytosis and spine head (epmc).pdf DeepDyve Pubget Overpricing