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10.1038/s41467-018-03628-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-03628-8 C5964315!5964315 !29581513     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29581513 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2018 ; 9 (1 ): 1234 Nephropedia Template TP {{tp|p=29581513 |t=2018. The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation |pdf=|usr=}}{{29581513 }} gab.com Text The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29581513 #FOAvip Intu is known as a ciliogenesis and planar polarity effector (CPLANE) protein. Although roles for Intu have been reported during embryonic development and in the context of developmental disorders, its function and regulation in adult tissues remain poorly understood. Here we show that ablation of Intu specifically in kidney proximal tubules aggravates renal ischemia-reperfusion injury, and leads to defective post-injury ciliogenesis. We identify signal transducer and activator of transcription 1 (STAT1) as a novel interacting partner of Intu. In vitro, Intu and STAT1 colocalize at the centriole/basal body area, and Intu promotes proteasomal degradation of STAT1. During cell stress, Intu expression preserves cilia length and cell viability, and these actions are antagonized by STAT1 expression. Thus, we propose a role for Intu in protecting cells and tissues after injury by targeting STAT1 for degradation and maintaining primary cilia. Twit Text FOAVip The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29581513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29581513 #FOAvip English Wikipedia <ref>{{Cite pmid|29581513 }}</ref> The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation #MMPMID29581513 Wang S ; Liu A ; Wu G ; Ding HF ; Huang S ; Nahman S ; Dong Z Nat Commun 2018[Mar]; 9 (1 ): 1234 PMID29581513 show ga Intu is known as a ciliogenesis and planar polarity effector (CPLANE) protein. Although roles for Intu have been reported during embryonic development and in the context of developmental disorders, its function and regulation in adult tissues remain poorly understood. Here we show that ablation of Intu specifically in kidney proximal tubules aggravates renal ischemia-reperfusion injury, and leads to defective post-injury ciliogenesis. We identify signal transducer and activator of transcription 1 (STAT1) as a novel interacting partner of Intu. In vitro, Intu and STAT1 colocalize at the centriole/basal body area, and Intu promotes proteasomal degradation of STAT1. During cell stress, Intu expression preserves cilia length and cell viability, and these actions are antagonized by STAT1 expression. Thus, we propose a role for Intu in protecting cells and tissues after injury by targeting STAT1 for degradation and maintaining primary cilia. |Animals [MESH] |Basal Bodies/metabolism [MESH] |Cell Death/physiology [MESH] |Centrioles/metabolism [MESH] |Cilia/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Kidney Tubules, Proximal/cytology/metabolism [MESH] |Kidney/*blood supply [MESH] |Membrane Proteins/genetics/*physiology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Protein Binding [MESH] |Proteolysis [MESH] |Rabbits [MESH] |Rats [MESH] |Reperfusion Injury/*prevention & control [MESH]The CPLANE protein Intu protects kidneys from ischemia-reperfusion inj(epmc).pdf DeepDyve Pubget Overpricing