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10.1038/s41419-018-0642-6 http://scihub22266oqcxt.onion/10.1038/s41419-018-0642-6 C5964200!5964200 !29789637     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29789637 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (6 ): 604 Nephropedia Template TP {{tp|p=29789637 |t=2018. The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses |pdf=|usr=}}{{29789637 }} gab.com Text The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29789637 #FOAvip Proton pump inhibitors (PPIs) play a role in antitumor activity, with studies showing specialized impacts of PPIs on cancer cell apoptosis, metastasis, and autophagy. In this study, we demonstrated that pantoprazole (PPI) increased autophagosomes formation and affected autophagic flux depending on the pH conditions. PPI specifically elevated SQSTM1 protein levels by increasing SQSTM1 transcription via NFE2L2 activation independent of the specific effect of PPI on autophagic flux. Via decreasing proteasome subunits expression, PPI significantly impaired the function of the proteasome, accompanied by the accumulation of undegraded poly-ubiquitinated proteins. Notably, PPI-induced autophagy functioned as a downstream response of proteasome inhibition by PPI, while suppressing protein synthesis abrogated autophagy. Blocking autophagic flux in neutral pH condition or further impairing proteasome function with proteasome inhibitors, significantly aggravated PPI cytotoxicity by worsening protein degradation ability. Interestingly, under conditions of mitochondrial stress, PPI showed significant synergism when combined with Bcl-2 inhibitors. Taken together, these findings provide a new understanding of the impact of PPIs on cancer cells' biological processes and highlight the potential to develop more efficient and effective combination therapies. Twit Text FOAVip The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29789637 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29789637 #FOAvip English Wikipedia <ref>{{Cite pmid|29789637 }}</ref> The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses #MMPMID29789637 Cao Y ; Chen M ; Tang D ; Yan H ; Ding X ; Zhou F ; Zhang M ; Xu G ; Zhang W ; Zhang S ; Zhuge Y ; Wang L ; Zou X Cell Death Dis 2018[May]; 9 (6 ): 604 PMID29789637 show ga Proton pump inhibitors (PPIs) play a role in antitumor activity, with studies showing specialized impacts of PPIs on cancer cell apoptosis, metastasis, and autophagy. In this study, we demonstrated that pantoprazole (PPI) increased autophagosomes formation and affected autophagic flux depending on the pH conditions. PPI specifically elevated SQSTM1 protein levels by increasing SQSTM1 transcription via NFE2L2 activation independent of the specific effect of PPI on autophagic flux. Via decreasing proteasome subunits expression, PPI significantly impaired the function of the proteasome, accompanied by the accumulation of undegraded poly-ubiquitinated proteins. Notably, PPI-induced autophagy functioned as a downstream response of proteasome inhibition by PPI, while suppressing protein synthesis abrogated autophagy. Blocking autophagic flux in neutral pH condition or further impairing proteasome function with proteasome inhibitors, significantly aggravated PPI cytotoxicity by worsening protein degradation ability. Interestingly, under conditions of mitochondrial stress, PPI showed significant synergism when combined with Bcl-2 inhibitors. Taken together, these findings provide a new understanding of the impact of PPIs on cancer cells' biological processes and highlight the potential to develop more efficient and effective combination therapies. |*Stress, Physiological [MESH] |Apoptosis/*drug effects [MESH] |Autophagosomes/drug effects/metabolism/ultrastructure [MESH] |Autophagy/drug effects [MESH] |Cell Line, Tumor [MESH] |Endoplasmic Reticulum Stress/drug effects [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Lysosomes/drug effects/metabolism [MESH] |Membrane Fusion/drug effects [MESH] |Membrane Proteins/metabolism [MESH] |NF-E2-Related Factor 2/metabolism [MESH] |Pantoprazole/chemistry/*pharmacology [MESH] |Proteasome Endopeptidase Complex/metabolism [MESH] |Proteasome Inhibitors/pharmacology [MESH] |Protein Biosynthesis/drug effects [MESH] |Proteolysis/*drug effects [MESH] |Proton Pump Inhibitors/chemistry/*pharmacology [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Sequestosome-1 Protein/genetics/metabolism [MESH] |Signal Transduction/drug effects [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Transcription, Genetic/drug effects [MESH] |Unfolded Protein Response/drug effects [MESH]The proton pump inhibitor pantoprazole disrupts protein degradation sy(epmc).pdf DeepDyve Pubget Overpricing