Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41419-018-0645-3 http://scihub22266oqcxt.onion/10.1038/s41419-018-0645-3 C5964149!5964149 !29789528     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29789528 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29789528 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (6 ): 591 Nephropedia Template TP {{tp|p=29789528 |t=2018. YAP-dependent ubiquitination and degradation of ?-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer |pdf=|usr=}}{{29789528 }} gab.com Text YAP-dependent ubiquitination and degradation of -catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29789528 #FOAvip Aberrant activation of Wnt/?-catenin signalling is critical in the progression of human cancers, especially colorectal cancer (CRC). Therefore, inhibition of Wnt/?-catenin signalling is a significant potential target for CRC therapy. Here, we identified for the first time that Physalin F (PF), a steroid derivative isolated from Physalis angulate, acts as an antagonist of Wnt/?-catenin signalling. In vitro, PF decreased Wnt3a-induced TOPFlash reporter activity in HEK293T cells and promoted the formation of the ?-catenin destruction complex. Importantly, PF also inhibited Wnt/?-catenin signalling and accelerated the degradation of ?-catenin in CRC cells. However, PF did not affect the stabilization of Axin or the interaction of ?-catenin with E-cadherin. Interestingly, we further found that PF promoted YAP binding to the ?-catenin destruction complex, which facilitated the ubiquitination and degradation of ?-catenin. Silencing and pharmacological inhibition of YAP reversed the formation of the ?-catenin destruction complex induced by PF, implying that YAP binding to the ?-catenin destruction complex was responsible for PF-mediated inhibition of Wnt/?-catenin signalling. Furthermore, PF observably inhibited tumour growth by down-regulating ?-catenin in tumour-bearing mice. Collectively, our findings indicated that PF inhibited Wnt/?-catenin signalling by accelerating the ubiquitination and degradation of ?-catenin in a YAP-dependent manner and therefore PF could be a novel potential candidate for CRC therapy. Twit Text FOAVip YAP-dependent ubiquitination and degradation of -catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29789528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29789528 #FOAvip English Wikipedia <ref>{{Cite pmid|29789528 }}</ref> YAP-dependent ubiquitination and degradation of ?-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer #MMPMID29789528 Chen C ; Zhu D ; Zhang H ; Han C ; Xue G ; Zhu T ; Luo J ; Kong L Cell Death Dis 2018[May]; 9 (6 ): 591 PMID29789528 show ga Aberrant activation of Wnt/?-catenin signalling is critical in the progression of human cancers, especially colorectal cancer (CRC). Therefore, inhibition of Wnt/?-catenin signalling is a significant potential target for CRC therapy. Here, we identified for the first time that Physalin F (PF), a steroid derivative isolated from Physalis angulate, acts as an antagonist of Wnt/?-catenin signalling. In vitro, PF decreased Wnt3a-induced TOPFlash reporter activity in HEK293T cells and promoted the formation of the ?-catenin destruction complex. Importantly, PF also inhibited Wnt/?-catenin signalling and accelerated the degradation of ?-catenin in CRC cells. However, PF did not affect the stabilization of Axin or the interaction of ?-catenin with E-cadherin. Interestingly, we further found that PF promoted YAP binding to the ?-catenin destruction complex, which facilitated the ubiquitination and degradation of ?-catenin. Silencing and pharmacological inhibition of YAP reversed the formation of the ?-catenin destruction complex induced by PF, implying that YAP binding to the ?-catenin destruction complex was responsible for PF-mediated inhibition of Wnt/?-catenin signalling. Furthermore, PF observably inhibited tumour growth by down-regulating ?-catenin in tumour-bearing mice. Collectively, our findings indicated that PF inhibited Wnt/?-catenin signalling by accelerating the ubiquitination and degradation of ?-catenin in a YAP-dependent manner and therefore PF could be a novel potential candidate for CRC therapy. |*Ubiquitination [MESH] |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Colorectal Neoplasms/*metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Male [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Phosphoproteins/*metabolism [MESH] |Proteasome Endopeptidase Complex/metabolism [MESH] |Protein Stability/drug effects [MESH] |Proteolysis/*drug effects [MESH] |Secosteroids/chemistry/*pharmacology [MESH] |Transcription Factors [MESH] |Wnt Signaling Pathway/*drug effects [MESH] |Xenograft Model Antitumor Assays [MESH] |YAP-Signaling Proteins [MESH] |beta Catenin/*metabolism [MESH]YAP-dependent ubiquitination and degradation of ?-catenin mediates inh(epmc).pdf DeepDyve Pubget Overpricing