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10.1253/circj.CJ-17-0229

http://scihub22266oqcxt.onion/10.1253/circj.CJ-17-0229
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C5964022!5964022!28420827
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suck abstract from ncbi


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pmid28420827      Circ+J 2017 ; 81 (6): 888-90
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  • Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms #MMPMID28420827
  • Howatt DA; Dajee M; Xie X; Moorleghen J; Rateri DL; Balakrishnan A; Da Cunha V; Johns DG; Gutstein DE; Daugherty A; Lu H
  • Circ J 2017[May]; 81 (6): 888-90 PMID28420827show ga
  • Background: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Methods and Results: Male C57BL/6 or apolipoprotein E?/? mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E?/? mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions: MMP-9 deficiency augmented AngII-induced AAA.
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