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10.1038/s41419-018-0594-x http://scihub22266oqcxt.onion/10.1038/s41419-018-0594-x C5962530!5962530 !29785022     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29785022 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (6 ): 579 Nephropedia Template TP {{tp|p=29785022 |t=2018. Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer |pdf=|usr=}}{{29785022 }} gab.com Text Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29785022 #FOAvip The clinical application of GX1, an optimal gastric cancer (GC) targeting peptide, is greatly limited because its receptor in the GC vasculature is unknown. In this study, we screened the candidate receptor of GX1, transglutaminase-2(TGM2), by co-immunoprecipitation (co-IP) combined with mass spectrometry. We found that TGM2 was up-regulated in GC vascular endothelial cells and that GX1 receptor expression was suppressed correspondingly after TGM2 downregulation. A highly consistent co-localization of GX1 receptor and TGM2 was detected at both the cellular and tissue levels. High TGM2 expression was evident in GC tissues from patients with poor prognosis. After TGM2 downregulation, the GX1-mediated inhibition of proliferation and migration and the induction of the apoptosis of GC vascular endothelial cells were weakened or even reversed. Finally, we observed that GX1 could inhibit the GTP-binding activity of TGM2 by reducing its intracellular distribution and downregulating its downstream molecular targets (nuclear factor-kappa B, NF-?B; hypoxia-inducible factor 1-?, HIF1?) in GC vascular endothelial cells. Our study confirms that peptide GX1 can inhibit angiogenesis by directly binding to TGM2, subsequently reducing the GTP-binding activity of TGM2 and thereby suppressing its downstream pathway(NF-?B/HIF1?). Our conclusions suggest that GX1/TGM2 may provide a new target for the diagnosis and treatment of GC. Twit Text FOAVip Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29785022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29785022 #FOAvip English Wikipedia <ref>{{Cite pmid|29785022 }}</ref> Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer #MMPMID29785022 Lei Z ; Chai N ; Tian M ; Zhang Y ; Wang G ; Liu J ; Tian Z ; Yi X ; Chen D ; Li X ; Yu P ; Hu H ; Xu B ; Jian C ; Bian Z ; Guo H ; Wang J ; Peng S ; Nie Y ; Huang N ; Hu S ; Wu K Cell Death Dis 2018[May]; 9 (6 ): 579 PMID29785022 show ga The clinical application of GX1, an optimal gastric cancer (GC) targeting peptide, is greatly limited because its receptor in the GC vasculature is unknown. In this study, we screened the candidate receptor of GX1, transglutaminase-2(TGM2), by co-immunoprecipitation (co-IP) combined with mass spectrometry. We found that TGM2 was up-regulated in GC vascular endothelial cells and that GX1 receptor expression was suppressed correspondingly after TGM2 downregulation. A highly consistent co-localization of GX1 receptor and TGM2 was detected at both the cellular and tissue levels. High TGM2 expression was evident in GC tissues from patients with poor prognosis. After TGM2 downregulation, the GX1-mediated inhibition of proliferation and migration and the induction of the apoptosis of GC vascular endothelial cells were weakened or even reversed. Finally, we observed that GX1 could inhibit the GTP-binding activity of TGM2 by reducing its intracellular distribution and downregulating its downstream molecular targets (nuclear factor-kappa B, NF-?B; hypoxia-inducible factor 1-?, HIF1?) in GC vascular endothelial cells. Our study confirms that peptide GX1 can inhibit angiogenesis by directly binding to TGM2, subsequently reducing the GTP-binding activity of TGM2 and thereby suppressing its downstream pathway(NF-?B/HIF1?). Our conclusions suggest that GX1/TGM2 may provide a new target for the diagnosis and treatment of GC. |Apoptosis/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation [MESH] |Down-Regulation/drug effects [MESH] |Endothelial Cells/*enzymology [MESH] |Female [MESH] |GTP-Binding Proteins/*metabolism [MESH] |Human Umbilical Vein Endothelial Cells/drug effects/metabolism/ultrastructure [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Neovascularization, Pathologic/*drug therapy [MESH] |Oligopeptides/pharmacology/*therapeutic use [MESH] |Peptides, Cyclic/pharmacology/*therapeutic use [MESH] |Prognosis [MESH] |Protein Glutamine gamma Glutamyltransferase 2 [MESH] |Stomach Neoplasms/*blood supply/pathology [MESH] |Transglutaminases/*metabolism [MESH]Novel peptide GX1 inhibits angiogenesis by specifically binding to t(epmc).pdf DeepDyve Pubget Overpricing