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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Org+Biomol+Chem 2009 ; 7 (8): 1508-24 Nephropedia Template TP
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Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function #MMPMID19343235
Fowler SA; Blackwell HE
Org Biomol Chem 2009[Apr]; 7 (8): 1508-24 PMID19343235show ga
Oligomers of N-substituted glycine, or peptoids, are versatile tools to probe biological processes and hold promise as therapeutic agents. An underlying theme in the majority of recent peptoid research is the connection between peptoid function and peptoid structure. For certain applications, well-folded peptoids are essential for activity, while unstructured peptoids appear to suffice, or even are superior, for other applications. Currently, these structure-function connections are largely made after the design, synthesis, and characterization process. However, as guidelines for peptoid folding are elucidated and the known biological activities are expanded, we anticipate these connections will provide a pathway toward the de novo design of functional peptoids. In this perspective, we review several of the peptoid structure-function relationships that have been delineated over the past five years.