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10.1016/j.celrep.2018.03.076 http://scihub22266oqcxt.onion/10.1016/j.celrep.2018.03.076 C5961503!5961503!29617664     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29617664&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2018 ; 23 (1): 239-254.e6 Nephropedia Template TP {{tp|p=29617664|t=2018. Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas |pdf=|usr=}}{{29617664}} gab.com Text Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29617664 #FOAvip DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ~20% of samples. Homologous recombination deficiency (HRD) was present at varying frequency in many cancer types, most notably ovarian cancer. However, in contrast to ovarian cancer, HRD was associated with worse outcomes in several other cancers. Protein structure-based analyses allowed us to predict functional consequences of rare, recurrent DDR mutations. A new machine-learning-based classifier developed from gene expression data allowed us to identify alterations that phenocopy deleterious TP53 mutations. These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy. Twit Text FOAVip Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29617664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29617664 #FOAvip English Wikipedia <ref>{{Cite pmid|29617664}}</ref> Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas #MMPMID29617664 Knijnenburg TA; Wang L; Zimmermann MT; Chambwe N; Gao GF; Cherniack AD; Fan H; Shen H; Way GP; Greene CS; Liu Y; Akbani R; Feng B; Donehower LA; Miller C; Shen Y; Karimi M; Chen H; Kim P; Jia P; Shinbrot E; Zhang S; Liu J; Hu H; Bailey MH; Yau C; Wolf D; Zhao Z; Weinstein JN; Li L; Ding L; Mills GB; Laird PW; Wheeler DA; Shmulevich I; Monnat RJ; Xiao Y; Wang C Cell Rep 2018[Apr]; 23 (1): 239-254.e6 PMID29617664show ga DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying loss of heterozygosity were observed in over 1/3 of DDR genes, including TP53 and BRCA1/2. Other prevalent alterations included epigenetic silencing of the direct repair genes EXO5, MGMT, and ALKBH3 in ~20% of samples. Homologous recombination deficiency (HRD) was present at varying frequency in many cancer types, most notably ovarian cancer. However, in contrast to ovarian cancer, HRD was associated with worse outcomes in several other cancers. Protein structure-based analyses allowed us to predict functional consequences of rare, recurrent DDR mutations. A new machine-learning-based classifier developed from gene expression data allowed us to identify alterations that phenocopy deleterious TP53 mutations. These frequent DDR gene alterations in many human cancers have functional consequences that may determine cancer progression and guide therapy. äGenomic and Molecular Landscape of DNA Damage Repair Deficiency across(epmc).pdf DeepDyve Pubget Overpricing