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10.22038/IJBMS.2018.26101.6412 http://scihub22266oqcxt.onion/10.22038/IJBMS.2018.26101.6412 C5960754!5960754!29796221     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Iran+J+Basic+Med+Sci 2018 ; 21 (4): 382-7 Nephropedia Template TP {{tp|p=29796221|t=2018. Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?|pdf=|usr=}}{{29796221}} gab.com Text Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity JO: Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=29796221 #FOAvip Objective(s):: To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods:: Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats were decapitated under anesthesia and incised kidney tissues were subjected to biochemical and histological examinations. Results:: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P?0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman?s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. There was a significant decrease in increased MDA, TOS, Bun, and creatinine levels, and a significant increase in decreased GSH, SOD, CAT, and TAS levels in CCl4 + crocin administered group compared to the CCl4 group (P?0.05), local minimal glomerular damage, tubular damage, inflammatory infiltration, and vascular collagen symptoms were observed in kidney sections, however significant improvement was observed in damage findings when compared to the CCl4 group. Conclusion:: At this dose and time interval, against a highly toxic chemical such as CCl4, crocin was able to suppress oxidative stress by playing a protective role in the kidney tissue. Twit Text FOAVip Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity ????Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=29796221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29796221 #FOAvip English Wikipedia <ref>{{Cite pmid|29796221}}</ref> Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity? #MMPMID29796221 Erdemli ME; Gul M; Altinoz E; Aksungur Z; Gul S; Bag HG Iran J Basic Med Sci 2018[Apr]; 21 (4): 382-7 PMID29796221show ga Objective(s):: To investigate protective role of crocin by attempting to create nephrotoxicity with carbon tetrachloride. Materials and Methods:: Ethics committee approval was obtained and 50 male Wistar rats were randomly divided into 5 groups that included 10 rats each: Control, Corn oil, Crocin, Carbon tetrachloride (CCl4), and Crocin + Carbon tetrachloride. Following the experiments, the rats were decapitated under anesthesia and incised kidney tissues were subjected to biochemical and histological examinations. Results:: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P?0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman?s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. There was a significant decrease in increased MDA, TOS, Bun, and creatinine levels, and a significant increase in decreased GSH, SOD, CAT, and TAS levels in CCl4 + crocin administered group compared to the CCl4 group (P?0.05), local minimal glomerular damage, tubular damage, inflammatory infiltration, and vascular collagen symptoms were observed in kidney sections, however significant improvement was observed in damage findings when compared to the CCl4 group. Conclusion:: At this dose and time interval, against a highly toxic chemical such as CCl4, crocin was able to suppress oxidative stress by playing a protective role in the kidney tissue. äCan crocin play a preventive role in Wistar rats with carbon tetrachlo(epmc).pdf DeepDyve Pubget Overpricing