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10.1007/s13238-018-0547-2 http://scihub22266oqcxt.onion/10.1007/s13238-018-0547-2 C5960471!5960471!29705929     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Protein+Cell 2018 ; 9 (5): 432-45 Nephropedia Template TP {{tp|p=29705929|t=2018. Pharmacomicrobiomics: a novel route towards personalized medicine?|pdf=|usr=}}{{29705929}} gab.com Text Pharmacomicrobiomics: a novel route towards personalized medicine JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=29705929 #FOAvip Inter-individual heterogeneity in drug response is a serious problem that affects the patient?s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recognized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition. Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposition (absorption, distribution, metabolism and excretion). In this review, we provide a historical overview and examine current state-of-the-art knowledge on the complex interactions between gut microbiome, host and drugs. We argue that combining pharmacogenomics and pharmacomicrobiomics will provide an important foundation for making major advances in personalized medicine. Twit Text FOAVip Pharmacomicrobiomics: a novel route towards personalized medicine ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=29705929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29705929 #FOAvip English Wikipedia <ref>{{Cite pmid|29705929}}</ref> Pharmacomicrobiomics: a novel route towards personalized medicine? #MMPMID29705929 Doestzada M; Vila AV; Zhernakova A; Koonen DPY; Weersma RK; Touw DJ; Kuipers F; Wijmenga C; Fu J Protein Cell 2018[May]; 9 (5): 432-45 PMID29705929show ga Inter-individual heterogeneity in drug response is a serious problem that affects the patient?s wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recognized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition. Pharmacomicrobiomics is an emerging field that investigates the interplay of microbiome variation and drugs response and disposition (absorption, distribution, metabolism and excretion). In this review, we provide a historical overview and examine current state-of-the-art knowledge on the complex interactions between gut microbiome, host and drugs. We argue that combining pharmacogenomics and pharmacomicrobiomics will provide an important foundation for making major advances in personalized medicine. äPharmacomicrobiomics: a novel route towards personalized medicine?(epmc).pdf DeepDyve Pubget Overpricing