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10.1007/s10545-017-0114-7 http://scihub22266oqcxt.onion/10.1007/s10545-017-0114-7 C5959966!5959966!29209936     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Inherit+Metab+Dis 2018 ; 41 (3): 489-98 Nephropedia Template TP {{tp|p=29209936|t=2018. Plasma lipidomics as a diagnostic tool for peroxisomal disorders |pdf=|usr=}}{{29209936}} gab.com Text Plasma lipidomics as a diagnostic tool for peroxisomal disorders JO: J Inherit Metab Dis http://www.kidney.de/pget.php?&tw=1&pmid=29209936 #FOAvip Peroxisomes are ubiquitous cell organelles that play an important role in lipid metabolism. Accordingly, peroxisomal disorders, including the peroxisome biogenesis disorders and peroxisomal single-enzyme deficiencies, are associated with aberrant lipid metabolism. Lipidomics is an emerging tool for diagnosis, disease-monitoring, identifying lipid biomarkers, and studying the underlying pathophysiology in disorders of lipid metabolism. In this study, we demonstrate the potential of lipidomics for the diagnosis of peroxisomal disorders using plasma samples from patients with different types of peroxisomal disorders. We show that the changes in the plasma profiles of phospholipids, di- and triglycerides, and cholesterol esters correspond with the characteristic metabolite abnormalities that are currently used in the metabolic screening for peroxisomal disorders. The lipidomics approach, however, gives a much more detailed overview of the metabolic changes that occur in the lipidome. Furthermore, we identified novel unique lipid species for specific peroxisomal diseases that are candidate biomarkers. The results presented in this paper show the power of lipidomics approaches to enable the specific diagnosis of different peroxisomal disorders.Electronic supplementary material: The online version of this article (10.1007/s10545-017-0114-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip Plasma lipidomics as a diagnostic tool for peroxisomal disorders ????J Inherit Metab Dis http://www.kidney.de/pget.php?&tw=1&pmid=29209936 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29209936 #FOAvip English Wikipedia <ref>{{Cite pmid|29209936}}</ref> Plasma lipidomics as a diagnostic tool for peroxisomal disorders #MMPMID29209936 Herzog K; Pras-Raves ML; Ferdinandusse S; Vervaart MAT; Luyf ACM; van Kampen AHC; Wanders RJA; Waterham HR; Vaz FM J Inherit Metab Dis 2018[]; 41 (3): 489-98 PMID29209936show ga Peroxisomes are ubiquitous cell organelles that play an important role in lipid metabolism. Accordingly, peroxisomal disorders, including the peroxisome biogenesis disorders and peroxisomal single-enzyme deficiencies, are associated with aberrant lipid metabolism. Lipidomics is an emerging tool for diagnosis, disease-monitoring, identifying lipid biomarkers, and studying the underlying pathophysiology in disorders of lipid metabolism. In this study, we demonstrate the potential of lipidomics for the diagnosis of peroxisomal disorders using plasma samples from patients with different types of peroxisomal disorders. We show that the changes in the plasma profiles of phospholipids, di- and triglycerides, and cholesterol esters correspond with the characteristic metabolite abnormalities that are currently used in the metabolic screening for peroxisomal disorders. The lipidomics approach, however, gives a much more detailed overview of the metabolic changes that occur in the lipidome. Furthermore, we identified novel unique lipid species for specific peroxisomal diseases that are candidate biomarkers. The results presented in this paper show the power of lipidomics approaches to enable the specific diagnosis of different peroxisomal disorders.Electronic supplementary material: The online version of this article (10.1007/s10545-017-0114-7) contains supplementary material, which is available to authorized users. äPlasma lipidomics as a diagnostic tool for peroxisomal disorders (epmc).pdf DeepDyve Pubget Overpricing