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10.1007/s10545-017-0118-3

http://scihub22266oqcxt.onion/10.1007/s10545-017-0118-3
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C5959963!5959963!29294191
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suck abstract from ncbi


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pmid29294191      J+Inherit+Metab+Dis 2018 ; 41 (3): 515-23
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  • Chemical glycomics enrichment: imaging the recycling of sialic acid in living cells #MMPMID29294191
  • Gilormini PA; Lion C; Vicogne D; Guérardel Y; Foulquier F; Biot C
  • J Inherit Metab Dis 2018[]; 41 (3): 515-23 PMID29294191show ga
  • The development of metabolic oligosaccharide engineering (MOE) over the past two decades enabled the bioimaging studies of glycosylation processes in physio-pathological contexts. Herein, we successfully applied the chemical reporter strategy to image the fate of sialylated glycoconjugates in healthy and sialin-deficient patient fibroblasts. This chemical glycomics enrichment is a powerful tool for tracking sialylated glycoconjugates and probing lysosomal recycling capacities. Thus, such strategies appear fundamental for the characterization of lysosomal storage diseases.
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