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2018 ; 97
(19
): e0595
Nephropedia Template TP
gab.com Text
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English Wikipedia
A successful treatment of severe systemic lupus erythematosus caused by occult
pulmonary infection-associated with hemophagocytic syndrome: A case report
#MMPMID29742693
Shi W
; Duan M
; Jie L
; Sun W
Medicine (Baltimore)
2018[May]; 97
(19
): e0595
PMID29742693
show ga
RATIONALE: A 27-year-old woman with a history of systemic lupus erythaematosus
(SLE) developed hemophagocytic syndrome (HPS) secondary due to an unrecognized
infection that led to severe SLE with a prolonged recovery. PATIENT CONCERNS: The
patient showed a high spiking fever and myalgia. Laboratory data revealed
pancytopenia and immunological abnormalities. Pulse methylprednisone plus
intravenous immunoglobulin (IVIG) failed to improve the clinical symptoms and
laboratory data. DIAGNOSES: As activated macrophages with hemophagocytosis were
confirmed in bone marrow histology, the patient was diagnosed as having reactive
HPS. INTERVENTIONS AND OUTCOMES: Her reactive HPS was successfully treated with
intravenous antibiotics and was followed by oral prednisolone and
hydroxychloroquine maintenance therapy. LESSONS: In severe SLE, patients with
persistent high fever, cytopenia, and elevated levels of serum ferritin and liver
enzymes should be strongly suspected of reactive HPS, and aggressive examination,
such as bone marrow biopsy, needs to be considered for early diagnosis and proper
treatment.