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10.20455/ros.2016.829 http://scihub22266oqcxt.onion/10.20455/ros.2016.829 C5959041!5959041!29780883     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       React+Oxyg+Species+(Apex) 2016 ; 1 (2): 141-56 Nephropedia Template TP {{tp|p=29780883|t=2016. Vitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killing Cancer Cells |pdf=|usr=}}{{29780883}} gab.com Text Vitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killing Cancer Cells JO: React Oxyg Species (Apex) http://www.kidney.de/pget.php?&tw=1&pmid=29780883 #FOAvip Early work in the 1970s by Linus Pauling, a twice-honored Nobel laureate, led to his proposal of using high-dose vitamin C to treat cancer patients. Over the past several decades, a number of studies in animal models as well as several small-scale clinical studies have provided substantial support of Linus Pauling?s early proposal. Production of reactive oxygen species (ROS) via oxidation of vitamin C appears to be a major underlying event, leading to the selective killing of cancer cells. However, it remains unclear how vitamin C selectively kills cancer cells while sparing normal cells and what the molecular targets of high-dose vitamin C are. In a recent article published in Science (2015 December 11; 350(6266):1391?6. doi: 10.1126/science.aaa5004), Yun et al. reported that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH) through an ROS-dependent mechanism. This work by Yun et al. along with other findings advances our current understanding of the molecular basis of high-dose vitamin C-mediated cancer cell killing, which will likely give an impetus to the continued research efforts aiming to further decipher the novel biochemistry of vitamin C and its unique role in cancer therapy. Twit Text FOAVip Vitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killing Cancer Cells ????React Oxyg Species (Apex) http://www.kidney.de/pget.php?&tw=1&pmid=29780883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29780883 #FOAvip English Wikipedia <ref>{{Cite pmid|29780883}}</ref> Vitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killing Cancer Cells #MMPMID29780883 Li R React Oxyg Species (Apex) 2016[Mar]; 1 (2): 141-56 PMID29780883show ga Early work in the 1970s by Linus Pauling, a twice-honored Nobel laureate, led to his proposal of using high-dose vitamin C to treat cancer patients. Over the past several decades, a number of studies in animal models as well as several small-scale clinical studies have provided substantial support of Linus Pauling?s early proposal. Production of reactive oxygen species (ROS) via oxidation of vitamin C appears to be a major underlying event, leading to the selective killing of cancer cells. However, it remains unclear how vitamin C selectively kills cancer cells while sparing normal cells and what the molecular targets of high-dose vitamin C are. In a recent article published in Science (2015 December 11; 350(6266):1391?6. doi: 10.1126/science.aaa5004), Yun et al. reported that vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH) through an ROS-dependent mechanism. This work by Yun et al. along with other findings advances our current understanding of the molecular basis of high-dose vitamin C-mediated cancer cell killing, which will likely give an impetus to the continued research efforts aiming to further decipher the novel biochemistry of vitamin C and its unique role in cancer therapy. äVitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killi(epmc).pdf DeepDyve Pubget Overpricing