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10.2147/DDDT.S159767 http://scihub22266oqcxt.onion/10.2147/DDDT.S159767 C5958949!5958949!29795978     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Des+Devel+Ther 2018 ; 12 (ä): 1239-54 Nephropedia Template TP {{tp|p=29795978|t=2018. Computer-aided design of amino acid-based therapeutics: a review |pdf=|usr=}}{{29795978}} gab.com Text Computer-aided design of amino acid-based therapeutics: a review JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=29795978 #FOAvip During the last two decades, the pharmaceutical industry has progressed from detecting small molecules to designing biologic-based therapeutics. Amino acid-based drugs are a group of biologic-based therapeutics that can effectively combat the diseases caused by drug resistance or molecular deficiency. Computational techniques play a key role to design and develop the amino acid-based therapeutics such as proteins, peptides and peptidomimetics. In this study, it was attempted to discuss the various elements for computational design of amino acid-based therapeutics. Protein design seeks to identify the properties of amino acid sequences that fold to predetermined structures with desirable structural and functional characteristics. Peptide drugs occupy a middle space between proteins and small molecules and it is hoped that they can target ?undruggable? intracellular protein?protein interactions. Peptidomimetics, the compounds that mimic the biologic characteristics of peptides, present refined pharmacokinetic properties compared to the original peptides. Here, the elaborated techniques that are developed to characterize the amino acid sequences consistent with a specific structure and allow protein design are discussed. Moreover, the key principles and recent advances in currently introduced computational techniques for rational peptide design are spotlighted. The most advanced computational techniques developed to design novel peptidomimetics are also summarized. Twit Text FOAVip Computer-aided design of amino acid-based therapeutics: a review ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=29795978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29795978 #FOAvip English Wikipedia <ref>{{Cite pmid|29795978}}</ref> Computer-aided design of amino acid-based therapeutics: a review #MMPMID29795978 Farhadi T; Hashemian SM Drug Des Devel Ther 2018[]; 12 (ä): 1239-54 PMID29795978show ga During the last two decades, the pharmaceutical industry has progressed from detecting small molecules to designing biologic-based therapeutics. Amino acid-based drugs are a group of biologic-based therapeutics that can effectively combat the diseases caused by drug resistance or molecular deficiency. Computational techniques play a key role to design and develop the amino acid-based therapeutics such as proteins, peptides and peptidomimetics. In this study, it was attempted to discuss the various elements for computational design of amino acid-based therapeutics. Protein design seeks to identify the properties of amino acid sequences that fold to predetermined structures with desirable structural and functional characteristics. Peptide drugs occupy a middle space between proteins and small molecules and it is hoped that they can target ?undruggable? intracellular protein?protein interactions. Peptidomimetics, the compounds that mimic the biologic characteristics of peptides, present refined pharmacokinetic properties compared to the original peptides. Here, the elaborated techniques that are developed to characterize the amino acid sequences consistent with a specific structure and allow protein design are discussed. Moreover, the key principles and recent advances in currently introduced computational techniques for rational peptide design are spotlighted. The most advanced computational techniques developed to design novel peptidomimetics are also summarized. äComputer-aided design of amino acid-based therapeutics: a review (epmc).pdf DeepDyve Pubget Overpricing