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Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression
in clear cell renal cell carcinoma
#MMPMID29749470
Cao Q
; Ruan H
; Wang K
; Song Z
; Bao L
; Xu T
; Xiao H
; Wang C
; Cheng G
; Tong J
; Meng X
; Liu D
; Yang H
; Chen K
; Zhang X
Int J Oncol
2018[Jul]; 53
(1
): 137-147
PMID29749470
show ga
Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in
adults, the incidence of which continues to increase. The lipid droplet protein
perilipin 2 (PLIN2), which was originally considered an RNA transcript, is
markedly expressed during adipocyte differentiation. In addition, it has been
observed to be elevated in numerous types of cancer, including ccRCC; however,
its essential function remains unclear in ccRCC. The present study examined the
expression of PLIN2 in ccRCC, and aimed to determine the association between
PLIN2 expression and patient survival. The present study mined the
transcriptional, clinicopathological and survival data of PLIN2 in patients with
ccRCC through The Cancer Genome Atlas. The expression levels of PLIN2 were also
detected in human ccRCC tissues and cell lines by western blotting and
immunohistochemistry, and its biological role was identified by functional
analysis. The results demonstrated that PLIN2 was predominantly elevated in RCC
tissues and cells. In addition, the expression levels of PLIN2 were significantly
associated with various clinicopathological factors, and high PLIN2 expression
was associated with a good prognosis. The results of a multivariate analysis
demonstrated that high PLIN2 expression was an independent prognostic indicator
of overall survival (hazard ratio, 0.586; P=0.001). Furthermore, PLIN2 knockdown
promoted proliferation of ccRCC cells, and enhanced cell invasion and migration.
These results suggested that PLIN2 may be considered a novel prognostic factor in
ccRCC and a specific diagnostic indicator for patients with ccRCC. Furthermore,
it could be a potential novel target for the clinical treatment of ccRCC.
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